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G-418 disulfate
G418硫酸氢盐 /G-418 disulfate
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货号：A261695
同义名：
遗传霉素硫酸盐(G-418 硫酸盐)
/ Geneticin sulfate;Antibiotic G-418 sulfate
G-418 disulfate (Genet icin sulfate) 是一种氨基糖苷类 抗生素 ，能抑制真核生物和原核生物的蛋白 质合成，常用于真核细胞的选择性药剂。
G-418 disulfate 化学结构
G-418 disulfate 3D分子结构
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G-418 disulfate 纯度/质量文件 产品仅供科研
货号：A261695
标准纯度：
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G-418 disulfate 质控信息
G-418 disulfate 生物活性
描述
Antibiotic G-418 is a new aminoglycoside produced by a new species of Micromonospora, M. rhodorangea NRRL 5326, with a similar structure to gentamicin B1 and has broad-spectrum antibacterial activity in vitro and in vivo, such as protozoa, amoebae, tapeworm, and pinworm infections in mice, and blocks polypeptide synthesis by inhibiting the elongation step in both prokaryotic and eukaryotic cells[3] Acanthamoeba trophozoites with IC50 and IC90 values of 32 ± 3 and 75 ± 5 μg/mL at 37 °C respectively and induced programmed cell death through the elevation of intracellular calcium and cytochrome c translocation[4] [5] Bacillus cereus [6]
G-418 disulfate 动物研究
Dose
Rat: 10 mg/kg[3] [4]
Administration
s.c., i.p.
G-418 disulfate 参考文献
[1] Li Y, Shang P, et al. Inhibitory effects of antisense RNA of HAb18G/CD147 on invasion of hepatocellular carcinoma cells in vitro. World J Gastroenterol. 2003 Oct;9(10):2174-7.
[2] Davies J, Jimenez A. A new selective agent for eukaryotic cloning vectors. Am J Trop Med Hyg. 1980 Sep;29(5 Suppl):1089-92.
[3] Wagman GH, Testa RT, Marquez JA, Weinstein MJ. Antibiotic G-418, a new Micromonospora-produced aminoglycoside with activity against protozoa and helminths: fermentation, isolation, and preliminary characterization. Antimicrob Agents Chemother. 1974 Aug;6(2):144-9. doi: 10.1128/AAC.6.2.144. PMID: 15828184; PMCID: PMC444619.
[4] Koutsogiannis Z, MacLeod ET, Maciver SK. G418 induces programmed cell death in Acanthamoeba through the elevation of intracellular calcium and cytochrome c translocation. Parasitol Res. 2019 Feb;118(2):641-651. doi: 10.1007/s00436-018-6192-0. Epub 2019 Jan 7. PMID: 30617503; PMCID: PMC6349814.
[5] Yallop CA, Svendsen I. The effects of G418 on the growth and metabolism of recombinant mammalian cell lines. Cytotechnology. 2001 Mar;35(2):101-14. doi: 10.1023/A:1017550902771. PMID: 19003287; PMCID: PMC3449461.
[6] Morris JC, Ping-Sheng L, Zhai HX, Shen TY, Mensa-Wilmot K. Phosphatidylinositol phospholipase C is activated allosterically by the aminoglycoside G418. 2-deoxy-2-fluoro-scyllo-inositol-1-O-dodecylphosphonate and its analogs inhibit glycosylphosphatidylinositol phospholipase C. J Biol Chem. 1996 Jun 28;271(26):15468-77. doi: 10.1074/jbc.271.26.15468. PMID: 8663028.
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G-418 disulfate 实验方案
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存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
1.44mL
0.29mL
0.14mL
7.22mL
1.44mL
0.72mL
14.44mL
2.89mL
1.44mL
G-418 disulfate 技术信息
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