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/ Fluticasone Propionate

氟替卡松丙酸酯 /Fluticasone Propionate {[allProObj[0].p_purity_real_show]}

货号：A558252 同义名： 丙酸氟替卡松 / Fluticasone (propionate);Fluticasone 17-Propionate

Fluticasone Propionate是一种糖皮质激素受体激动剂，具有强亲和力 (KD = 0.5 nM)，主要用于治疗过敏性鼻炎和哮喘，几乎不与其他甾体受体结合。

Fluticasone Propionate 化学结构 CAS号：80474-14-2
Fluticasone Propionate 化学结构
CAS号：80474-14-2
Fluticasone Propionate 3D分子结构
CAS号：80474-14-2
Fluticasone Propionate 化学结构 CAS号：80474-14-2
Fluticasone Propionate 3D分子结构 CAS号：80474-14-2
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Fluticasone Propionate 纯度/质量文件 产品仅供科研

货号：A558252 标准纯度： {[allProObj[0].p_purity_real_show]}
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Fluticasone Propionate 生物活性

描述 Fluticasone propionate is a new corticosteroid based on the androstane nucleus. It is more lipophilic than beclomethasone dipropionate (BDP) and budesonide, and binds more avidly to human lung tissue. It has an absolute affinity (KD) of 0.5 nM for the glucocorticoid receptor and a relative receptor affinity 1.5- and 3.0-times greater than that of beclomethasone-17-monopropionate (17-BMP) and budesonide, respectively. The rate of association with the receptor is faster and the rate of dissociation slower than with standard corticosteroids. Pretreatment with fluticasone propionate significantly inhibits the increase in mast cell numbers in the nasal mucosa of rats chronically exposed to toluene di-isocyanate (TDI), and suppresses TDI-induced mast cell degranulation. Fluticasone propionate therefore has increased intrinsic glucocorticoid potency and high topical anti-inflammatory activity[3]. Fluticasone propionate is a potent topical anti-inflammatory corticosteroid with low systemic activity. Fluticasone propionate generally demonstrated similar efficacy compared with intranasal beclomethasone dipropionate, flunisolide acetonide and oral astemizole and better or a trend towards better efficacy compared with oral loratadine, terfenadine, cetirizine and intranasal sodium cromoglycate (cromolyn sodium) against nasal symptoms[4]. Inhaled fluticasone propionate < or =500 microg/day is an effective anti-inflammatory therapy for mild to moderate asthma in adolescents and adults[5].

Fluticasone Propionate 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01381471 - Completed - -
NCT01381471 - Completed - -
NCT01431924 - Completed - -

Fluticasone Propionate 参考文献

[1]Papi A, Price D, et al. Efficacy of fluticasone propionate/formoterol fumarate in the treatment of asthma: a pooled analysis. Respir Med. 2015 Feb;109(2):208-17.

[2]Muley P, Shah M, et al. Safety of inhaled fluticasone propionate therapy for pediatric asthma - a systematic review. Curr Drug Saf. 2013 Jul;8(3):186-94.

[3]Johnson M. The anti-inflammatory profile of fluticasone propionate. Allergy. 1995;50(23 Suppl):11-4

[4]Bryson HM, Faulds D. Intranasal fluticasone propionate. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in allergic rhinitis. Drugs. 1992 May;43(5):760-75.

[5]Jarvis B, Faulds D. Inhaled fluticasone propionate: a review of its therapeutic efficacy at dosages < or = 500 microg/day in adults and adolescents with mild to moderate asthma. Drugs. 1999 May;57(5):769-803

Fluticasone Propionate 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.00mL

0.40mL

0.20mL

9.99mL

2.00mL

1.00mL

19.98mL

4.00mL

2.00mL

Fluticasone Propionate 技术信息

CAS号80474-14-2
分子式C25H31F3O5S
分子量 500.571
别名 丙酸氟替卡松 ;Fluticasone (propionate);Fluticasone 17-Propionate;Fluticasone Propionate, Cutivate, Flixonase, Flixotide, Flonase, Flovent;CCI-187881
运输蓝冰
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Sealed in dry,Store in freezer, under -20°C
溶解方案

DMSO: 105 mg/mL(209.76 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
方案一
动物实验配方

Tags: Fluticasone (propionate) | 80474-14-2 | Glucocorticoid Receptor | Enterovirus | Glucocorticoid Receptor Agonist | Immunology/Inflammation | Vitamin D Related/Nuclear Receptor | Anti-infection | Metabolic Enzyme/Protease | Glucocorticoid Receptor | Enterovirus | Endogenous Metabolite | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Fluticasone Propionate 纯度/质量文件 | Fluticasone Propionate 生物活性 | Fluticasone Propionate 临床数据 | Fluticasone Propionate 参考文献 | Fluticasone Propionate 实验方案 | Fluticasone Propionate 技术信息

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