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氟吡呋喃酮 /Flupyradifurone {[allProObj[0].p_purity_real_show]}

货号:A1256938

Flupyradifurone是一种烟碱乙酰胆碱受体 (nAChR) 激动剂,能干扰害虫的中枢神经系统信号传导,可作为杀虫剂

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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Flupyradifurone 化学结构 CAS号:951659-40-8
Flupyradifurone 化学结构
CAS号:951659-40-8
Flupyradifurone 3D分子结构
CAS号:951659-40-8
Flupyradifurone 化学结构 CAS号:951659-40-8
Flupyradifurone 3D分子结构 CAS号:951659-40-8
规格 价格 会员价 库存 数量
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Flupyradifurone 纯度/质量文件 产品仅供科研

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Flupyradifurone 生物活性

描述 Flupyradifurone acts as a systemic nAChR agonist disrupting signal transduction in the central nervous systems of sucking pests and is used as a butenolide insecticide[1].
体内研究

The half-life of Flupyradifurone in peppers ranges from 2.6 to 3.8 days, with a national estimated daily intake being 0.00094 mg/kg[3].

体外研究

Flupyradifurone is a butenolide insecticide that activates insect nicotinic acetylcholine receptors (nAChRs). It is also regarded as being beneficial to the health of honey bees[1].

Flupyradifurone (FLF) competes with imidacloprid (IMI) for binding to the same high-affinity site on the insect nAChR, the modulation of which results in toxicity[2].

Flupyradifurone 参考文献

[1]Yi Guo, et al. The Effects of Exposure to Flupyradifurone on Survival, Development, and Foraging Activity of Honey Bees (Apis mellifera L.) under Field Conditions. Insects. 2021 Apr 16;12(4):357.

[2]Mark Montgomery, et al. Structural Biology-Guided Design, Synthesis, and Biological Evaluation of Novel Insect Nicotinic Acetylcholine Receptor Orthosteric Modulators. J Med Chem. 2022 Jan 5.

[3]Yizhi Feng, et al. Determination, residue analysis, dietary risk assessment, and processing of flupyradifurone and its metabolites in pepper under field conditions using LC-MS/MS. Biomed Chromatogr. 2022 Jan 3;e5312.

Flupyradifurone 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.46mL

0.69mL

0.35mL

17.32mL

3.46mL

1.73mL

34.64mL

6.93mL

3.46mL

Flupyradifurone 技术信息

CAS号951659-40-8
分子式C12H11ClF2N2O2
分子量 288.678
别名
运输蓝冰
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Inert atmosphere,2-8°C

溶解方案

DMSO: 105 mg/mL(363.73 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液,再依次添加助溶剂:
——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议现用现配,当天使用; 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶
方案一
方案二
动物实验配方
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