There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type | HazMat fee for 500 gram (Estimated) |
Excepted Quantity | USD 0.00 |
Limited Quantity | USD 15-60 |
Inaccessible (Haz class 6.1), Domestic | USD 80+ |
Inaccessible (Haz class 6.1), International | USD 150+ |
Accessible (Haz class 3, 4, 5 or 8), Domestic | USD 100+ |
Accessible (Haz class 3, 4, 5 or 8), International | USD 200+ |
规格 | 价格 | 会员价 | 库存 | 数量 | |||
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快速发货 顺丰冷链运输,1-2 天到达
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免费溶解
描述 | Fluoxetine is the first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants. Fluoxetine blocks the downregulation of cell proliferation resulting from inescapable shock (IS) of hippocampal cell. Fluoxetine treatment also reverses the deficit in escape latency observed in animals exposed to inescapable shock in adult male Sprague-Dawley rats[3].Fluoxetine increases the number of newborn cells in the dentate gyrus of the hippocampus of adult rat. Fluoxetine also increases the number of proliferating cells in the prelimbic cortex. Fluoxetine (5 mg/kg) alone increases cell proliferation in the dentate gyrus. Coadministration (fluoxetine 5 mg/kg + olanzapine) also significantly increases the number of BrdU-positive cells compared with the control group[4].Fluoxetine accelerates the maturation of immature neurons. Fluoxetine enhances neurogenesis-dependent long-term potentiation (LTP) in the dentate gyrus[5].Fluoxetine, but not citalopram, fluvoxamine, paroxetine and sertraline, increases norepinephrine and dopamine extracellular levels in prefrontal cortex. Fluoxetine produces robust and sustained increases in extracellular concentrations of norepinephrine and dopamine after acute systemic administration[6].Fluoxetine combined with Olanzapine produces robust, sustained increases of extracellular levels of dopamine ([DA](ex)) and norepinephrine ([NE](ex)) up to 361% and 272% of the baseline, respectively, which are significantly greater than either drug alone[7]. |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
NCT02473250 | Bipolar Disorder | Phase 4 | Recruiting | September 2019 | United States, New York ... 展开 >> New York State Psychiatric Institute/Columbia University Medical Center Recruiting New York, New York, United States, 10032 Contact: Martin Lan, MD PHD 646-774-7610 martin.lan@NYSPI.COLUMBIA.EDU 收起 << |
NCT00451490 | Depressive Disorder, Major | Not Applicable | Withdrawn(This study not get t... 展开 >>he approval by the drug company) 收起 << | December 2007 | Taiwan ... 展开 >> National Taiwan University Hospital Taipei, Taiwan, 100 收起 << |
NCT01488266 | Major Depressive Disorder | Not Applicable | Unknown | March 2013 | Korea, Republic of ... 展开 >> Korean Univ Ansan Hospital; Bucheon St.Mary Hospital; DonggukUniv Gyeongju Hospital; Catholic University of Korea St. Paul's Hospital Seoul, Korea, Republic of Taiwan Chang Gung Memorial Hospital; Kaohsiung Medical University Chung-ho Memorial Hospital Taipei, Taiwan 收起 << |
计算器 | ||||
存储液制备 | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
3.23mL 0.65mL 0.32mL |
16.16mL 3.23mL 1.62mL |
32.33mL 6.47mL 3.23mL |
CAS号 | 54910-89-3 |
分子式 | C17H18F3NO |
分子量 | 309.33 |
SMILES Code | FC(C1=CC=C(OC(C2=CC=CC=C2)CCNC)C=C1)(F)F |
MDL No. | MFCD00072041 |
别名 | LY-110140 free base |
运输 | 蓝冰 |
InChI Key | RTHCYVBBDHJXIQ-UHFFFAOYSA-N |
Pubchem ID | 3386 |
存储条件 |
In solvent -20°C:1个月-80°C:12个月 |
溶解方案 |
DMSO: 105 mg/mL(339.45 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO |