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首页 / 抑制剂/激动剂 / 神经信号通路 / SSRIs / Fluoxetine

氟西汀 /Fluoxetine {[allProObj[0].p_purity_real_show]}

货号：A411004 同义名： LY-110140 free base

Fluoxetine (LY-110140 游离碱) 是一种选择性 5-羟色胺再摄取抑制剂 (SSRI)，用于抗抑郁研究。

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Fluoxetine 化学结构 CAS号：54910-89-3
Fluoxetine 化学结构
CAS号：54910-89-3
Fluoxetine 3D分子结构
CAS号：54910-89-3
Fluoxetine 化学结构 CAS号：54910-89-3
Fluoxetine 3D分子结构 CAS号：54910-89-3
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Fluoxetine 纯度/质量文件 产品仅供科研

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Fluoxetine 生物活性

描述 Fluoxetine is the first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants. Fluoxetine blocks the downregulation of cell proliferation resulting from inescapable shock (IS) of hippocampal cell. Fluoxetine treatment also reverses the deficit in escape latency observed in animals exposed to inescapable shock in adult male Sprague-Dawley rats[3].Fluoxetine increases the number of newborn cells in the dentate gyrus of the hippocampus of adult rat. Fluoxetine also increases the number of proliferating cells in the prelimbic cortex. Fluoxetine (5 mg/kg) alone increases cell proliferation in the dentate gyrus. Coadministration (fluoxetine 5 mg/kg + olanzapine) also significantly increases the number of BrdU-positive cells compared with the control group[4].Fluoxetine accelerates the maturation of immature neurons. Fluoxetine enhances neurogenesis-dependent long-term potentiation (LTP) in the dentate gyrus[5].Fluoxetine, but not citalopram, fluvoxamine, paroxetine and sertraline, increases norepinephrine and dopamine extracellular levels in prefrontal cortex. Fluoxetine produces robust and sustained increases in extracellular concentrations of norepinephrine and dopamine after acute systemic administration[6].Fluoxetine combined with Olanzapine produces robust, sustained increases of extracellular levels of dopamine ([DA](ex)) and norepinephrine ([NE](ex)) up to 361% and 272% of the baseline, respectively, which are significantly greater than either drug alone[7].

Fluoxetine 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02473250 Bipolar Disorder Phase 4 Recruiting September 2019 United States, New York ... 展开 >> New York State Psychiatric Institute/Columbia University Medical Center Recruiting New York, New York, United States, 10032 Contact: Martin Lan, MD PHD    646-774-7610    martin.lan@NYSPI.COLUMBIA.EDU 收起 <<
NCT00451490 Depressive Disorder, Major Not Applicable Withdrawn(This study not get t... 展开 >>he approval by the drug company) 收起 << December 2007 Taiwan ... 展开 >> National Taiwan University Hospital Taipei, Taiwan, 100 收起 <<
NCT01488266 Major Depressive Disorder Not Applicable Unknown March 2013 Korea, Republic of ... 展开 >> Korean Univ Ansan Hospital; Bucheon St.Mary Hospital; DonggukUniv Gyeongju Hospital; Catholic University of Korea St. Paul's Hospital Seoul, Korea, Republic of Taiwan Chang Gung Memorial Hospital; Kaohsiung Medical University Chung-ho Memorial Hospital Taipei, Taiwan 收起 <<

Fluoxetine 参考文献

[1]Wang JW, David DJ, et al. Chronic fluoxetine stimulates maturation and synaptic plasticity of adult-born hippocampal granule cells. J Neurosci. 2008 Feb 6;28(6):1374-84.

[2]Malberg JE, Duman RS. Cell proliferation in adult hippocampus is decreased by inescapable stress: reversal by fluoxetine treatment. Neuropsychopharmacology. 2003 Sep;28(9):1562-71.

[3]Malberg JE, et al. Cell proliferation in adult hippocampus is decreased by inescapable stress: reversal by fluoxetine treatment. Neuropsychopharmacology. 2003 Sep;28(9):1562-71.

[4]Kodama M, et al. Chronic olanzapine or fluoxetine administration increases cell proliferation in hippocampus and prefrontal cortex of adult rat. Biol Psychiatry. 2004 Oct 15;56(8):570-80.

[5]Wang JW, et al. Chronic fluoxetine stimulates maturation and synaptic plasticity of adult-born hippocampal granule cells. J Neurosci. 2008 Feb 6;28(6):1374-84.

[6]Bymaster FP, et al. Fluoxetine, but not other selective serotonin uptake inhibitors, increases norepinephrine and dopamine extracellular levels in prefrontal cortex. Psychopharmacology (Berl). 2002 Apr;160(4):353-61.

[7]Zhang W, et al. Synergistic effects of olanzapine and other antipsychotic agents in combination with fluoxetine on norepinephrine and dopamine release in rat prefrontal cortex. Neuropsychopharmacology. 2000 Sep;23(3):250-62.

Fluoxetine 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.23mL

0.65mL

0.32mL

16.16mL

3.23mL

1.62mL

32.33mL

6.47mL

3.23mL

Fluoxetine 技术信息

CAS号54910-89-3
分子式C17H18F3NO
分子量 309.326
别名 LY-110140 free base
运输蓝冰
存储条件

液体 -20°C:1个月-80°C:12个月
溶解度

DMSO: 105 mg/mL(339.45 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

Tags: Fluoxetine | LY-110140 free base | SSRIs | AmBeed-信号通路专用抑制剂 | Fluoxetine 纯度/质量文件 | Fluoxetine 生物活性 | Fluoxetine 临床数据 | Fluoxetine 参考文献 | Fluoxetine 实验方案 | Fluoxetine 技术信息

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