The neuroprotective effects of Ethoxyquin are dose-dependent. While all three tested doses provide some degree of neuroprotection against reductions in intraepidermal nerve fiber density, the maximum effectiveness is achieved at a dose of 75 μg/kg^[2].

In experimental settings, rats treated with Ethoxyquin alone or with a control vehicle exhibit expected weight gain under normal physiological conditions^[3].

Ethoxyquin (EQ) does not inhibit Paclitaxel's (PTX) ability to induce cell death in four different breast cancer cell lines. Importantly, the neuroprotective effect of Ethoxyquin is only observable when Hsp90 levels are not reduced; a decrease in Hsp90 abrogates this neuroprotection^[2].

Ethoxyquin is most effective as a neuroprotectant at concentrations ranging from 30 to 300 nM. Higher concentrations in the micromolar (μM) range fail to enhance neuroprotection and, in fact, result in the loss of these neuroprotective properties^[3].