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首页 / 抑制剂/激动剂 / 神经信号通路 / SSRIs / Escitalopram/艾司西酞普兰

Escitalopram/艾司西酞普兰 {[allProObj[0].p_purity_real_show]}

货号：A247040 同义名： 依他普仑 / (S)-(+)-Citalopram; (S)-Citalopram

Escitalopram is a selective serotonin reuptake inhibitor (SSRI) with Ki of 0.89 nM.

Escitalopram/艾司西酞普兰 化学结构 CAS号：128196-01-0
Escitalopram/艾司西酞普兰 化学结构
CAS号：128196-01-0
Escitalopram/艾司西酞普兰 3D分子结构
CAS号：128196-01-0
Escitalopram/艾司西酞普兰 化学结构 CAS号：128196-01-0
Escitalopram/艾司西酞普兰 3D分子结构 CAS号：128196-01-0
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Escitalopram/艾司西酞普兰 纯度/质量文件 产品仅供科研

货号：A247040 标准纯度： {[allProObj[0].p_purity_real_show]}
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Escitalopram/艾司西酞普兰 生物活性

描述 The serotonergic system in the brain modulates many types of behavioural and physiological processes. An example of this modulatory function is seen with the selective serotonin reuptake inhibitors (SSRIs) which enhance serotonin transmission and influence mood, anxiety states, aggression, feeding and sexual behaviour[3]. SSRIs are widely used antidepressants characterized by less-frequent adverse effects compared with classical anti-depressive agents. On the other hand, SSRI can cause hemorrhagic events more due to impaired platelet aggregation induced by a depletion of serotonin in the peripheral platelet[4].Escitalopram ((S)-Citalopram), the S-enantiomer of racemic Citalopram, is a SSRI with a Ki of 0.89 nM. Escitalopram has ∼30 fold higher binding affinity than its R(-)-enantiomer and shows selectivity over both dopamine transporter (DAT) and norepinephrine transporter (NET). Escitalopram is an antidepressant for the research of major depression[5].Escitalopram (10 mg/kg; i.p.; daily for 28 days) ameliorates cognitive impairments and selectively attenuates phosphorylated tau accumulation in stressed rats[6].Chronic administration of Escitalopram (daily; drinking water for a total of 4 months) significantly reduces plaque load by 28% and 34% at 2.5 and 5 mg/d, respectively[7].

Escitalopram/艾司西酞普兰 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00707863 Major Depression Phase 4 Completed - United States, Indiana ... 展开 >> Indiana University Adult Psychiatric Clinic Indianapolis, Indiana, United States, 46202 收起 <<
NCT00707863 - Completed - -
NCT00232700 Major Depressive Disorder Not Applicable Completed - Germany ... 展开 >> Department of Psychiatry, Charité - Universitaetsmedizin Berlin, Campus Benjamin Franklin Berlin, Germany, 14050 收起 <<

Escitalopram/艾司西酞普兰 参考文献

[1]Pastoor D, Gobburu J. Clinical pharmacology review of escitalopram for the treatment of depression. Expert Opin Drug Metab Toxicol. 2014 Jan;10(1):121-8.

[2]Zhang P, Cyriac G, et al. Structure-activity relationships for a novel series of citalopram (1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile) analogues at monoamine transporters. J Med Chem. 2010 Aug 26;53(16):6112-21.

[3] B Olivier,R van Oorschot, M D Waldinger. Serotonin, serotonergic receptors, selective serotonin reuptake inhibitors and sexual behaviour. Int Clin Psychopharmacol.1998 Jul;13 Suppl 6:S9-14.

[4]Takatsugu Yamamoto, Koichiro Abe, Yasushi Kuyama. Selective serotonin reuptake inhibitor and gastrointestinal hemorrhage. Nihon Rinsho. 2013 Apr;71(4):751-6.

[5]Zhang, P., et al., Structure-activity relationships for a novel series of citalopram (1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbon itrile) analogues at monoamine transporters. J Med Chem, 2010. 53(16): p. 6112-21.

[6]Wu C , et al. Escitalopram alleviates stress-induced Alzheimer's disease-like tau pathologies and cognitive deficits by reducing hypothalamic-pituitary-adrenal axis reactivity and insulin/GSK-3β signal pathway activity. Neurobiol Aging. 2018;67:137-147.

[7]Cirrito JR, et al. Effect of escitalopram on Aβ levels and plaque load in an Alzheimer mouse model. Neurology. 2020;95(19):e2666-e2674.

Escitalopram/艾司西酞普兰 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.08mL

0.62mL

0.31mL

15.41mL

3.08mL

1.54mL

30.83mL

6.17mL

3.08mL

Escitalopram/艾司西酞普兰 技术信息

CAS号128196-01-0
分子式C20H21FN2O
分子量 324.39
SMILES Code N#CC1=CC2=C([C@@](C3=CC=C(F)C=C3)(CCCN(C)C)OC2)C=C1
MDL No. MFCD09817397
别名 依他普仑 ;(S)-(+)-Citalopram; (S)-Citalopram; Seroplex
运输蓝冰
InChI Key WSEQXVZVJXJVFP-FQEVSTJZSA-N
Pubchem ID 146570
存储条件

In solvent -20°C:3-6个月-80°C:12个月
溶解方案

DMSO: 105 mg/mL(323.68 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
方案一
方案二

Tags: Escitalopram | 128196-01-0 | (S)-Citalopram | (S)-(+)-Citalopram | Serotonin Reuptake Inhibitor | Neuronal Signaling | Serotonin Transporter | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Escitalopram/艾司西酞普兰 纯度/质量文件 | Escitalopram/艾司西酞普兰 生物活性 | Escitalopram/艾司西酞普兰 临床数据 | Escitalopram/艾司西酞普兰 参考文献 | Escitalopram/艾司西酞普兰 实验方案 | Escitalopram/艾司西酞普兰 技术信息

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