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Esaxerenone {[allProObj[0].p_purity_real_show]}

货号:A165209 同义名: CS-3150;XL-550 Ambeed 开学季,买赠积分,赢豪礼

Esaxerenone is an aldosterone receptor antagonist. Esaxerenone may be potential useful for preventing or treating hypertension or disease caused by hypertension.

Esaxerenone 化学结构 CAS号:1632006-28-0
Esaxerenone 化学结构
CAS号:1632006-28-0
Esaxerenone 3D分子结构
CAS号:1632006-28-0
Esaxerenone 化学结构 CAS号:1632006-28-0
Esaxerenone 3D分子结构 CAS号:1632006-28-0
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Esaxerenone 纯度/质量文件 产品仅供科研

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Esaxerenone 生物活性

描述 Esaxerenone is recognized as a highly effective and selective antagonist for the non-steroidal mineralocorticoid receptor[1].

Esaxerenone 动物研究

Animal study Following a single oral dose of Esaxerenone at 0.1, 0.3, 1, and 3 mg/kg, there is a dose-dependent increase in both the maximum plasma concentration (Cmax) and the area under the plasma concentration-time curve (AUC). The Tmax, or the time to reach Cmax, varies from 2.0 to 4.5 hours. With intravenous doses of Esaxerenone at the same concentrations, the total body clearance (CL) ranges from 3.53 to 6.69 mL/min/kg and the steady-state distribution volume (Vss) from 1.47 to 2.49 L/kg in rats, while in cynomolgus monkeys, the CL is 2.79 to 3.69 mL/min/kg and the Vss is 1.34 to 1.54 L/kg. Post-administration, up to 168 hours, rats excrete 3.9% of the radioactivity in urine and 91.4% in feces, totaling 95.2%. In monkeys, 11.5% is excreted in urine, 82.3% in feces, and 93.9% in total within the same timeframe[1].

Esaxerenone 参考文献

[1]Yamada M, et al. Pharmacokinetics, distribution, and disposition of esaxerenone, a novel, highly potent and selective non-steroidal mineralocorticoid receptor antagonist, in rats and monkeys. Xenobiotica. 2017 Dec;47(12):1090-1103.

Esaxerenone 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.14mL

0.43mL

0.21mL

10.72mL

2.14mL

1.07mL

21.44mL

4.29mL

2.14mL

Esaxerenone 技术信息

CAS号1632006-28-0
分子式C22H21F3N2O4S
分子量 466.473
别名 CS-3150;XL-550
运输蓝冰
存储条件

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月

溶解度

DMSO: 105 mg/mL(225.09 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方
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