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恩诺沙星 /Enrofloxacin {[allProObj[0].p_purity_real_show]}

货号:A127543 同义名: BAY Vp 2674;PD160788

Enrofloxacin is a fluoroquinolone antibiotic used as a veterinary antibacterial agent.

Enrofloxacin 化学结构 CAS号:93106-60-6
Enrofloxacin 化学结构
CAS号:93106-60-6
Enrofloxacin 3D分子结构
CAS号:93106-60-6
Enrofloxacin 化学结构 CAS号:93106-60-6
Enrofloxacin 3D分子结构 CAS号:93106-60-6
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Enrofloxacin 纯度/质量文件 产品仅供科研

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Enrofloxacin 生物活性

描述 Enrofloxacin (EF) is an extensively used animal-specific antibacterial agent that leaves drug residues in the environment[3]. The in vivo effectiveness of enrofloxacin against E. coli in different organs varied, with the Emax ranging from - 4.4 to - 5.8 Log10 colony forming units (cfu)/mL or cfu/g. The AUC0-24/MIC ratio of the combination of enrofloxacin and ciprofloxacin producing bactericidal and elimination effects were 21.29 and 32.13 in blood; 41.68, and 58.52 in the liver; and 27.65 and 46.22 in the lung, respectively[4]. The most effective antibiotics tested in vitro were fluoroquinolones (MIC90 danofloxacin 0.312 μg/mL, enrofloxacin 0.312 μg/mL, marbofloxacin 0.625 μg/mL)[5]. Enrofloxacin reduced C. jejuni cell densities within the cecal and colonic digesta for all treatments, and densities shed in feces as a function of antibiotic duration[6].

Enrofloxacin 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03575312 Healthy Not Applicable Completed - Germany ... 展开 >> Fraunhofer Institute for Toxicology and Experimental Medicine Hannover, Germany, 30625 收起 <<

Enrofloxacin 参考文献

[1]Kung K, Riond JL, Wanner M. Pharmacokinetics of enrofloxacin and its metabolite ciprofloxacin after intravenous and oral administration of enrofloxacin in dogs. J Vet Pharmacol Ther. 1993 Dec;16(4):462-8.

[2]Prescott JF, Yielding KM. In vitro susceptibility of selected veterinary bacterial pathogens to ciprofloxacin, enrofloxacin and norfloxacin. Can J Vet Res. 1990 Jan;54(1):195-7.

[3]Lu X, Li Y, Thunders M, et al. Effect of enrofloxacin on the proteome of earthworms. Sci Total Environ. 2018;616-617:531–542

[4]Xiao X, Jiang L, Lan W, Jiang Y, Wang Z. in vivo pharmacokinetic/Pharmacodynamic modeling of Enrofloxacin against Escherichia coli in broiler chickens. BMC Vet Res. 2018;14(1):374.

[5]Sulyok KM, Kreizinger Z, Fekete L, et al. Antibiotic susceptibility profiles of Mycoplasma bovis strains isolated from cattle in Hungary, Central Europe. BMC Vet Res. 2014;10:256.

[6]Inglis GD, Zaytsoff SJM, Selinger LB, Taboada EN, Uwiera RRE. Therapeutic administration of enrofloxacin in mice does not select for fluoroquinolone resistance in Campylobacter jejuni. Can J Microbiol. 2018;64(10):681–694

Enrofloxacin 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.78mL

0.56mL

0.28mL

13.91mL

2.78mL

1.39mL

27.82mL

5.56mL

2.78mL

Enrofloxacin 技术信息

CAS号93106-60-6
分子式C19H22FN3O3
分子量 359.395
别名 BAY Vp 2674;PD160788;endrofloxicin.;CFPQ;Enrofloxacine;Baytril;ENR
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,Room Temperature

溶解度

DMSO: 9 mg/mL(25.04 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

H2O: 1 mg/mL(2.78 mM),配合低频超声,并水浴加热至45℃助溶

动物实验配方
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