恩诺沙星 /Enrofloxacin
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货号：A127543
同义名：
BAY Vp 2674;PD160788
Enrofloxacin is a fluoroquinolone antibiotic used as a veterinary antibacterial agent.
Enrofloxacin 化学结构
Enrofloxacin 3D分子结构
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Enrofloxacin 纯度/质量文件 产品仅供科研
货号：A127543
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Enrofloxacin 质控信息
Enrofloxacin 生物活性
描述
Enrofloxacin (EF) is an extensively used animal-specific antibacterial agent that leaves drug residues in the environment[3] in vivo effectiveness of enrofloxacin against E. coli in different organs varied, with the Emax ranging from - 4.4 to - 5.8 Log10 colony forming units (cfu)/mL or cfu/g. The AUC0-24/MIC ratio of the combination of enrofloxacin and ciprofloxacin producing bactericidal and elimination effects were 21.29 and 32.13 in blood; 41.68, and 58.52 in the liver; and 27.65 and 46.22 in the lung, respectively[4] in vitro were fluoroquinolones (MIC90 danofloxacin 0.312 μg/mL, enrofloxacin 0.312 μg/mL, marbofloxacin 0.625 μg/mL)[5] [6]
Enrofloxacin 临床研究
NCT号
适应症或疾病
临床期
招募状态
预计完成时间
地点
NCT03575312
Healthy
Not Applicable
Completed
-
Germany
... 展开 >> Fraunhofer Institute for Toxicology and Experimental Medicine
Hannover, Germany, 30625 收起 <<
Enrofloxacin 参考文献
[1] Kung K, Riond JL, Wanner M. Pharmacokinetics of enrofloxacin and its metabolite ciprofloxacin after intravenous and oral administration of enrofloxacin in dogs. J Vet Pharmacol Ther. 1993 Dec;16(4):462-8.
[2] Prescott JF, Yielding KM. In vitro susceptibility of selected veterinary bacterial pathogens to ciprofloxacin, enrofloxacin and norfloxacin. Can J Vet Res. 1990 Jan;54(1):195-7.
[3] Lu X, Li Y, Thunders M, et al. Effect of enrofloxacin on the proteome of earthworms. Sci Total Environ. 2018;616-617:531–542
[4] Xiao X, Jiang L, Lan W, Jiang Y, Wang Z. in vivo pharmacokinetic/Pharmacodynamic modeling of Enrofloxacin against Escherichia coli in broiler chickens. BMC Vet Res. 2018;14(1):374.
[5] Sulyok KM, Kreizinger Z, Fekete L, et al. Antibiotic susceptibility profiles of Mycoplasma bovis strains isolated from cattle in Hungary, Central Europe. BMC Vet Res. 2014;10:256.
[6] Inglis GD, Zaytsoff SJM, Selinger LB, Taboada EN, Uwiera RRE. Therapeutic administration of enrofloxacin in mice does not select for fluoroquinolone resistance in Campylobacter jejuni. Can J Microbiol. 2018;64(10):681–694
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Enrofloxacin 实验方案
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摩尔计算器
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1mg
5mg
10mg
1 mM
5 mM
10 mM
2.78mL
0.56mL
0.28mL
13.91mL
2.78mL
1.39mL
27.82mL
5.56mL
2.78mL
Enrofloxacin 技术信息
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