Enoxacin Sesquihydrate is a broad-spectrum fluoroquinolone antibacterial agent used in the treatment of urinary tract infections and gonorrhea, working by inhibiting bacterial DNA gyrase andtopoisomerase IV.
Enoxacin (Sesquihydrate) is a new quinolone carboxylic acid compound. It inhibited 90% Escherichia coli, Klebsiella sp., Aeromonas sp., Enterobacter spp., Serratia spp., Proteus mirabilis, and Morganella morganii at less than or equal to 0.8 micrograms/ml. Enoxacin inhibited organisms resistant to cefotaxime, moxalactam, gentamicin, and piperacillin[3]. It has a broad spectrum of in vitro antibacterial activity, and is particularly potent against Gram-negative organisms and staphylococci. Significantly (p less than 0.01) more clinical and/or bacteriological cures were effected by enoxacin than pipemidic acid in acute cystitis and complicated urinary tract infection[4]. Enoxacin and bis-enoxacin trigger the release of EVs (Extracellular vesicles) from 4T1 cancer cells that inhibit osteoclastogenesis[5]. UVA (ultraviolet A) irradiation activates enoxacin, after which activated enoxacin induces apoptosis of AsPC1 cells through generation of reactive oxygen species[6].
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