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Emeramide {[allProObj[0].p_purity_real_show]}

货号:A724926 同义名: NBMI;BDTH2 Ambeed 开学季,买赠积分,赢豪礼

Emeramide 是一种抗氧化剂和重金属螯合剂,通过调控细胞周期、转录因子以及抗氧化和抗炎机制,展示了其在癌症和神经退行性疾病治疗中的潜在应用。

Emeramide 化学结构 CAS号:351994-94-0
Emeramide 化学结构
CAS号:351994-94-0
Emeramide 3D分子结构
CAS号:351994-94-0
Emeramide 化学结构 CAS号:351994-94-0
Emeramide 3D分子结构 CAS号:351994-94-0
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Emeramide 纯度/质量文件 产品仅供科研

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Emeramide 生物活性

描述 Emeramide is a thiol-redox antioxidant and heavy metal chelator[1].
体内研究

Moreover, at a dose of 450 mg/kg administered orally daily for 6 weeks, Emeramide significantly reduces iron accumulation in Hfe H67D mutant mice, a model representing brain iron accumulation[4].

体外研究

Emeramide offers protection against Bleomycin-induced morphological changes and cytotoxicity in BPAECs at a concentration of 50 μM for 1 hour, reduces ROS generation, and attenuates Bleomycin-induced depletion of cellular total thiols[2].

When pre-treated for 24 hours with doses ranging from 0 to 100 μM, Emeramide effectively counters Pb-induced neuroinflammation in U-87 MG cells by diminishing IL-1β and GFAP expression levels[3].

Emeramide 参考文献

[1]Secor JD, et al. Novel lipid-soluble thiol-redox antioxidant and heavy metal chelator, N,N'-bis(2-mercaptoethyl)isophthalamide (NBMI) and phospholipase D-specific inhibitor, 5-fluoro-2-indolyl des-chlorohalopemide (FIPI) attenuate mercury-induced lipid signaling leading to protection against cytotoxicity in aortic endothelial cells. Int J Toxicol. 2011 Dec;30(6):619-38.

[2]Patel RB, et al. Thiol-redox antioxidants protect against lung vascular endothelial cytoskeletal alterations caused by pulmonary fibrosis inducer, bleomycin: comparison between classical thiol-protectant, N-acetyl-L-cysteine, and novel thiol antioxidant, N,N'-bis-2-mercaptoethyl isophthalamide. Toxicol Mech Methods. 2012 Jun;22(5):383-96.

[3]Gadde R, et al. N,N'bis-(2-mercaptoethyl) isophthalamide (NBMI) exerts neuroprotection against lead-induced toxicity in U-87 MG cells. Arch Toxicol. 2021 Aug;95(8):2643-2657.

[4]Cheng R, et al. Reversal of genetic brain iron accumulation by N,N'-bis(2-mercaptoethyl)isophthalamide, a lipophilic metal chelator, in mice. Arch Toxicol. 2022 Jul;96(7):1951-1962.

Emeramide 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.52mL

0.70mL

0.35mL

17.58mL

3.52mL

1.76mL

35.16mL

7.03mL

3.52mL

Emeramide 技术信息

CAS号351994-94-0
分子式C12H16N2O2S2
分子量 284.398
别名 NBMI;BDTH2;trade names B9, MetX, OSR, OSR#1.;N,N'-Bis(2-mercaptoethyl)isophthalamide;BDETH2;BDET
运输蓝冰
存储条件

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月

溶解度

DMSO: 105 mg/mL(369.2 mM),配合低频超声,并水浴加热至45℃助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方
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