Ambeed.cn

首页 / / / IL / EC330

EC330 {[allProObj[0].p_purity_real_show]}

货号:A723732 Ambeed 开学季,买赠积分,赢豪礼

EC330 is an inhibitor of leukemia inhibitory factor (LIF).

EC330 化学结构 CAS号:2016795-77-8
EC330 化学结构
CAS号:2016795-77-8
EC330 3D分子结构
CAS号:2016795-77-8
EC330 化学结构 CAS号:2016795-77-8
EC330 3D分子结构 CAS号:2016795-77-8
规格 价格 会员价 库存 数量
{[ item.pr_size ]}

{[ getRatePrice(item.pr_rmb, 1,1) ]}

{[ getRatePrice(item.pr_rmb_sale, 1,1) ]}

{[ getRatePrice(item.pr_rmb, 1,1) ]}

{[ getRatePrice(item.pr_rmb,item.pr_rate,1) ]}
{[ getRatePrice(item.pr_rmb, 1,1) ]} {[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_rmb,1,item.mem_rate) ]} 现货 咨询 - +
购物车0 收藏 询单

EC330 纯度/质量文件 产品仅供科研

货号:A723732 标准纯度: {[allProObj[0].p_purity_real_show]}
批次查询: 批次纯度:

全球学术期刊中引用的产品

JACS Au, 2024. Ambeed. [ A148168 ]
JMC, 2024. Ambeed. [ A187643 ]
JMC, 2024. Ambeed. [ A341145 , A633512 , A607865 , A167774 ]
Biomacromolecules, 2024. Ambeed. [ A110759 ]
Biomacromolecules, 2024. Ambeed. [ A203543 ]
更多 >

EC330 生物活性

描述 Leukemia inhibitory factor (LIF) is a pleiotropic cytokine that belongs to the interleukin-6 family. The overexpression of LIF is associated with tumor growth and low relapse-free survival rate. EC330 is a novel, orally bioavailable, steroidal LIF inhibitor that shows cytotoxicity in NCI-60 cell line panel and different types of cancer cell lines at low nanomolar concentration. It also blocked the colony formation and angiogenesis in HUVEC cells. EC330 demonstrated higher specificity in LIF-overexpressing MCF-7 cells versus wild-type MCF-7 cells. It disrupted cytoskeleton and targeted cancer-associated fibroblasts via the inhibition of alpha-SMA. In xenograft mouse models of ovarian (IGROV-1) and triple negative breast cancer (MDA-MB-231) cells, as well as the model of MDA-MB-231 patient-derived xenograft, treatment with EC330 at 0.1, 0.5 and 2.5mg/kg decreased tumor burden at a dose-dependent manner compared to the control group[1].

EC330 动物研究

Dose Mice: 0.1 mg/kg - 2.5 mg/kg[1] (p.o.)
Administration p.o.

EC330 参考文献

[1]Discovery and preclinical pharmacology of EC330: A first-in-class leukemia inhibitory factor (LIF) inhibitor

EC330 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.16mL

0.43mL

0.22mL

10.81mL

2.16mL

1.08mL

21.62mL

4.32mL

2.16mL

EC330 技术信息

CAS号2016795-77-8
分子式C30H32F2O2
分子量 462.571
别名
运输蓝冰
存储条件

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月

溶解度

DMSO: 18 mg/mL(38.91 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方
Ambeed 相关网站 Ambeed.cn Ambeed.com
Ambeed
关于我们
联系我们
资讯中心
网站地图
产品手册
  • 批次文件查询
  • 客户支持
    专业术语
    缩略词释义
    质量手册
    产品咨询
    计算器
    活动政策
    订购方法
    活动声明
    联系我们
    400-920-2911 sales@ambeed.cn tech@ambeed.cn
    Ambeed 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务,不为任何个人或者非科研性质用途提供服务。