Doxepin HCl | 盐酸多塞平 (异构体混合物) | Doxepin (hydrochloride) | Antidepressant

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盐酸多塞平 /Doxepin HCl {[allProObj[0].p_purity_real_show]}

货号：A783435 同义名： 盐酸多塞平 (异构体混合物) / Doxepin (hydrochloride);Doxepin Hydrochloride

Doxepin HCl, a tricyclic antidepressant, is antagonist of histamine H1 Receptor (Kd = 310 pM) and histamine H4 receptor (pKi = 6.79). It can be used to treat chronic idiopathic urticaria.

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Doxepin HCl 化学结构
CAS号：1229-29-4

Doxepin HCl 3D分子结构
CAS号：1229-29-4

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Doxepin HCl 纯度/质量文件产品仅供科研

货号：A783435 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

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Doxepin HCl 生物活性

描述

Doxepin hydrochloride is a potent and selective histamine receptor H1 antagonist. Doxepin hydrochloride is also a potent CYP450 inhibitor and significantly inhibits CYP450 2C19 and 1A2^[3]. Doxepin hydrochloride is an orally active tricyclic antidepressant agent^[4]. In addition, intrathecally administered doxepin, like bupivacaine and lidocaine, produced dose-related spinal anesthetic effects on motor activity, proprioception, and nociception. Doxepin produced spinal anesthetic effects in rats more potent than that of lidocaine and longer than that of bupivacaine and lidocaine^[5]. Doxepin displayed a very high affinity for H1 histamine receptor, being 8-fold more potent than mepyramine. Doxepin showed significant H2 blocking activity which was 5 times less potent than that of cimetidine. Doxepin competitively antagonized carbachol in the guinea pig ileum, and was 107 times less potent than atropine^[6]. In PC3 cells, doxepin induced a [Ca²⁺](i) rise by evoking PLC-independent Ca²⁺ release from stores including the endoplasmic reticulum and Ca²⁺ entry via PKC-sensitive store-operated Ca²⁺ channels. Doxepin caused cell death that was independent of [Ca²⁺](i) rises^[7].

Doxepin HCl 临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02191358	-		Completed	-	United States, California ... 展开 >> Dr. Michael Dao Garden Grove, California, United States, 92844 United States, Colorado Kaiser Permanente Colorado Denver, Colorado, United States, 80011 United States, Kentucky Gill Heart Institute Lexington, Kentucky, United States, 40508 United States, Maryland IRC Clinics Towson, Maryland, United States, 21204 United States, Massachusetts Internal Medicine & Cardiology Associates Fall River, Massachusetts, United States, 02720 Prima CARE Fall River, Massachusetts, United States, 02720 United States, Virginia Carilion Clinic Christiansburg, Virginia, United States, 24073 收起 <<
NCT02374567	Dementia Depr... 展开 >>ession Schizophrenia Psychosomatic Disorders Anxiety Disorders 收起 <<	Phase 3	Terminated	-	Germany ... 展开 >> Bezirkskrankenhaus Augsburg Augsburg, Germany Krankenhaus Hedwigshöhe Berlin, Germany Hannover Medical School Hannover, Germany, 30625 Asklepios Fachklinikum Lübben Lübben, Germany Asklepios Fachklinikum Teupitz Teupitz, Germany 收起 <<
NCT02297126	Adverse Drug Reaction	Not Applicable	Completed	-	United States, Indiana ... 展开 >> Eskenazi Health System Indianapolis, Indiana, United States, 46250 收起 <<

Doxepin HCl 参考文献

[1]Nguyen T, Shapiro DA, et al. Discovery of a novel member of the histamine receptor family. Mol Pharmacol. 2001 Mar;59(3):427-33.

[2]Luchins DJ. Review of clinical and animal studies comparing the cardiovascular effects of doxepin and other tricyclic antidepressants. Am J Psychiatry. 1983 Aug;140(8):1006-9.

[3]Hajak G, Rodenbeck A, Voderholzer U, Riemann D, Cohrs S, Hohagen F, Berger M, Rüther E. Doxepin in the treatment of primary insomnia: a placebo-controlled, double-blind, polysomnographic study. J Clin Psychiatry. 2001 Jun;62(6):453-63

[4]Singh H, Becker PM. Novel therapeutic usage of low-dose doxepin hydrochloride. Expert Opin Investig Drugs. 2007 Aug;16(8):1295-305

[5]Cheng BC, Chan BR, Chen YW, Chu KS, Cheng KI, Wang JJ, Chu CC. Doxepin has a potent and long-acting spinal anesthetic effect in rats. Kaohsiung J Med Sci. 2006 Feb;22(2):68-74

[6]Figueiredo A, Ribeiro CA, Gonçalo M, Almeida L, Poiares-Baptista A, Teixeira F. Mechanism of action of doxepin in the treatment of chronic urticaria. Fundam Clin Pharmacol. 1990;4(2):147-58

[7]Lu T, Chou CT, Liang WZ, Yu CC, Chang HT, Kuo CC, Chen WC, Kuo DH, Ho CM, Shieh P, Jan CR. Effect of Antidepressant Doxepin on Ca²⁺ Homeostasis and Viability in PC3 Human Prostate Cancer Cells. Chin J Physiol. 2015 Jun 30;58(3):178-87

Doxepin HCl 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

3.17mL

0.63mL

0.32mL

15.83mL

3.17mL

1.58mL

31.66mL

6.33mL

3.17mL

Doxepin HCl 技术信息

CAS号	1229-29-4
分子式	C₁₉H₂₂ClNO
分子量	315.837

别名	盐酸多塞平 (异构体混合物) ;Doxepin (hydrochloride);Doxepin Hydrochloride
运输	蓝冰

存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,Room Temperature

溶解度

DMSO: 105 mg/mL(332.45 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H₂O: 50 mg/mL(158.31 mM)

动物实验配方

临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT02191358	-		Completed	-	United States, California ... 展开 >> Dr. Michael Dao Garden Grove, California, United States, 92844 United States, Colorado Kaiser Permanente Colorado Denver, Colorado, United States, 80011 United States, Kentucky Gill Heart Institute Lexington, Kentucky, United States, 40508 United States, Maryland IRC Clinics Towson, Maryland, United States, 21204 United States, Massachusetts Internal Medicine & Cardiology Associates Fall River, Massachusetts, United States, 02720 Prima CARE Fall River, Massachusetts, United States, 02720 United States, Virginia Carilion Clinic Christiansburg, Virginia, United States, 24073 收起 <<
NCT02374567	Dementia Depr... 展开 >>ession Schizophrenia Psychosomatic Disorders Anxiety Disorders 收起 <<	Phase 3	Terminated	-	Germany ... 展开 >> Bezirkskrankenhaus Augsburg Augsburg, Germany Krankenhaus Hedwigshöhe Berlin, Germany Hannover Medical School Hannover, Germany, 30625 Asklepios Fachklinikum Lübben Lübben, Germany Asklepios Fachklinikum Teupitz Teupitz, Germany 收起 <<
NCT02297126	Adverse Drug Reaction	Not Applicable	Completed	-	United States, Indiana ... 展开 >> Eskenazi Health System Indianapolis, Indiana, United States, 46250 收起 <<
NCT02893371	-		Enrolling by invitation	June 2019	United States, New Mexico ... 展开 >> Christophe G Lambert Albuquerque, New Mexico, United States, 87131 收起 <<
NCT01489982	Parkinson's Disease ... 展开 >> Insomnia 收起 <<	Early Phase 1	Completed	-	Canada, Quebec ... 展开 >> Montreal General Hospital Montreal, Quebec, Canada, H3G1A4 收起 <<
NCT00704860	Major Depression	Phase 4	Completed	-	Canada, Ontario ... 展开 >> University of Ottawa Institute of Mental Health Research Ottawa, Ontario, Canada, K1Z 7K4 收起 <<
NCT02449096	Ankle Fractures	Not Applicable	Recruiting	June 2025	Germany ... 展开 >> Ludwig Maximilians University, LMU, Munich Recruiting Munich, Bavaria, Germany, 80336 Contact: Hans Polzer, PD Dr. med. 0049-89-4400-52511 Hans.Polzer@med.uni-muenchen.de Contact: Mareen Braunstein, Dr. med. 0049-89-4400-52511 Mareen.Braunstein@med.uni-muenchen.de 收起 <<
NCT00465972	HIV Infections ... 展开 >> Insomnia 收起 <<	Phase 4	Completed	-	United States, North Carolina ... 展开 >> Duke University Medical Center Durham, North Carolina, United States, 27710 收起 <<
NCT01268709	Irritable Bowel Syndrome	Phase 2	Completed	-	Iran, Islamic Republic of ... 展开 >> Gastrointestinal Research center,Beheshti Hospital Qom, Iran, Islamic Republic of, 1677859642 收起 <<
NCT00465972	-		Completed	-	-
NCT02229539	Acute Oral Mucositis Pain	Phase 3	Completed	-	-
NCT02229539	-		Completed	-	-
NCT02353299	-		Completed	-	-
NCT00755495	Sleep Initiation and Maintenan... 展开 >>ce Disorders 收起 <<	Phase 2	Completed	-	-
NCT02447211	Breast Cancer	Phase 2	Unknown	January 2017	Iran, Islamic Republic of ... 展开 >> Isfahan University of Medical Sciences Recruiting Isfahan, Iran, Islamic Republic of, 81745-319 Contact: Golnaz Vaseghi, Ph.D golnazvaseghi@yahoo.com Contact: Alireza Amouheidari, MD amouheidari@yahoo.com 收起 <<
NCT01156142	-		Completed	-	-
NCT03758079	Uremic Pruritus	Phase 4	Completed	-	Lebanon ... 展开 >> Saint George Hospital University Medical Center Beirut, Lebanon 收起 <<
NCT02353299	Healthy	Phase 4	Completed	-	United States, Michigan ... 展开 >> Henry Ford Hospital Sleep Disorders & Research Center Novi, Michigan, United States, 48377 收起 <<
NCT02062632	Esophageal Carcinoma ... 展开 >> Hypopharyngeal Carcinoma Laryngeal Carcinoma Lymphoma Mesothelioma Metastatic Malignant Neoplasm in the Lung Metastatic Malignant Neoplasm in the Pleura Metastatic Malignant Neoplasm in the Spinal Cord Non-Small Cell Lung Carcinoma Sarcoma Small Cell Lung Carcinoma Thymic Carcinoma Thymoma Thyroid Gland Carcinoma 收起 <<	Not Applicable	Completed	-	United States, Minnesota ... 展开 >> Mayo Clinic Rochester, Minnesota, United States, 55905 United States, Nebraska University of Nebraska Medical Center Omaha, Nebraska, United States, 68198 United States, Wisconsin Green Bay Oncology Limited at Saint Mary's Hospital Green Bay, Wisconsin, United States, 54303 收起 <<
NCT01156142	Head and Neck Cancer ... 展开 >> Mucositis Oral Complications of Radiation Therapy Pain 收起 <<	Phase 3	Completed	-	-

盐酸多塞平 /Doxepin HCl {[allProObj[0].p_purity_real_show]}

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全球学术期刊中引用的产品

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Doxepin HCl 参考文献

Doxepin HCl 实验方案

Doxepin HCl 技术信息

最近浏览的产品

大规格询价

摩尔计算器

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总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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