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泼尼松龙21-磷酸二钠 /Disodium Prednisolone 21-Phosphate {[allProObj[0].p_purity_real_show]}

货号:A791525 同义名: 泼尼松龙磷酸钠 / Prednisolone 21-phosphate disodium;Prednisolone disodium phosphate

Prednisolone disodium phosphate is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.

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Disodium Prednisolone 21-Phosphate 化学结构 CAS号:125-02-0
Disodium Prednisolone 21-Phosphate 化学结构
CAS号:125-02-0
Disodium Prednisolone 21-Phosphate 3D分子结构
CAS号:125-02-0
Disodium Prednisolone 21-Phosphate 化学结构 CAS号:125-02-0
Disodium Prednisolone 21-Phosphate 3D分子结构 CAS号:125-02-0
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Disodium Prednisolone 21-Phosphate 纯度/质量文件 产品仅供科研

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Disodium Prednisolone 21-Phosphate 生物活性

描述 Prednisolone disodium phosphate is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. It is hydrolyzed to prednisolone in vivo. Prednisolone phosphate (10 mg/kg), administered in long-circulating liposomes, decreases inflammation and the levels of IL-1β in the synovium, as well as reduces damage to the cartilage matrix in a mouse model of antigen-induced arthritis[3]. It also reduces tumor growth in B16/F10 melanoma and C26 colon carcinoma mouse models when administered in long-circulating liposomes at a dose of 20 mg/kg[4].

Disodium Prednisolone 21-Phosphate 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00241982 Rheumatoid Arthritis Phase 2 Completed - Netherlands ... 展开 >> Radboud University Nijmegen Medical Centre Nijmegen, Gelderland, Netherlands, 6500 HB 收起 <<

Disodium Prednisolone 21-Phosphate 参考文献

[1]Lambrou GI, Vlahopoulos S, et al. Prednisolone exerts late mitogenic and biphasic effects on resistant acute lymphoblastic leukemia cells: Relation to early gene expression. Leuk Res. 2009 Dec;33(12):1684-95.

[2]Matts SG. A comparison of sustained-release prednisolone disodium phosphate with prednisolone in the treatment of reversible bronchospasm. Br J Clin Pract. 1972 Sep;26(9):418-20.

[3]Hofkens W, Storm G, van den Berg WB, van Lent PL. Liposomal targeting of glucocorticoids to the inflamed synovium inhibits cartilage matrix destruction during murine antigen-induced arthritis. Int J Pharm. 2011;416(2):486-492.

[4]Schiffelers RM, Metselaar JM, Fens MH, Janssen AP, Molema G, Storm G. Liposome-encapsulated prednisolone phosphate inhibits growth of established tumors in mice. Neoplasia. 2005 Feb;7(2):118-27.

Disodium Prednisolone 21-Phosphate 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.06mL

0.41mL

0.21mL

10.32mL

2.06mL

1.03mL

20.64mL

4.13mL

2.06mL

Disodium Prednisolone 21-Phosphate 技术信息

CAS号125-02-0
分子式C21H27Na2O8P
分子量 484.388
别名 泼尼松龙磷酸钠 ;Prednisolone 21-phosphate disodium;Prednisolone disodium phosphate;Prednisolone Sodium Phosphate;Prednisolone Phosphate (sodium salt);Hydeltrasol
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,Room Temperature

溶解度

H2O: 50 mg/mL(103.22 mM),配合低频超声助溶

动物实验配方
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