Dirithromycin is a new macrolide with a spectrum and degree of in vitro antimicrobial activity similar to that of erythromycin. Multicentre double-blind clinical trials have shown dirithromycin to be similar in efficacy to erythromycin in the treatment of uncomplicated bacterial infections of the respiratory tract and of skin and soft tissues[3]. Dirithromycin offers some attractive pharmacokinetic properties. The long elimination half-life of dirithromycin allows once-daily dosing and higher and more prolonged tissue concentrations than are achievable with erythromycin[4]. Dirithromycin achieves relatively high tissue concentrations (approximately 0.8 - 5.0 mg/kg) 4 - 24 h after dosing[5]. The presence of dirithromycin slightly increased the intraphagocytic killing of Staphylococcus aureus in human PMNs (polymorphonuclear leukocytes)[6].
Jordan
... 展开 >> Arab Pharmaceutical industry Consulting/ Pharmaceutical Research Unit
Not yet recruiting
Amman, Jordan, 11941
Principal Investigator: Rana T Bustami, Ph.D. Pharmacy 收起 <<
Jordan
... 展开 >> Arab Pharmaceutical industry Consulting/ Pharmaceutical Research Unit
Not yet recruiting
Amman, Jordan, 11941
Principal Investigator: Rana T Bustami, Ph.D. Pharmacy 收起 <<
Jordan
... 展开 >> Arab Pharmaceutical industry Consulting/ Pharmaceutical Research Unit
Not yet recruiting
Amman, Jordan, 11941
Principal Investigator: Rana T Bustami, Ph.D. Pharmacy 收起 <<
United States, Kentucky
... 展开 >>
University of Louisville
Recruiting
Louisville, Kentucky, United States, 40202
Contact: Julio A Ramirez, MD 502-852-1148 jarami01@louisville.edu
Contact: David Seligson, MD 502-852-0923 d0seli01@louisville.edu
Sub-Investigator: Forest Arnold, DO
Sub-Investigator: Timothy Wiemkwn, PhD
Sub-Investigator: Robert Kelley, PhD
Sub-Investigator: James Summersgill, PhD
Sub-Investigator: Ruth Carrico, PhD
Sub-Investigator: Julie Harting, PharmD
Sub-Investigator: Paula Peyrani, MD
Principal Investigator: David Seligson, MD
Sub-Investigator: Craig Roberts, MD
Principal Investigator: Julio Ramirez, MD 收起 <<
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