Ambeed.cn

首页 / 抑制剂/激动剂 / / GNRH受体 / Degarelix

地加瑞克 /Degarelix {[allProObj[0].p_purity_real_show]}

货号:A890488 同义名: Degarelix游离 / Degarelix acetate Ambeed 开学季,买赠积分,赢豪礼

Degarelix is a gonadotrophin-releasing hormone (GnRH) antagonist for the first-line treatment of androgen-dependent advanced prostate cancer.

Degarelix 化学结构 CAS号:214766-78-6
Degarelix 化学结构
CAS号:214766-78-6
Degarelix 3D分子结构
CAS号:214766-78-6
Degarelix 化学结构 CAS号:214766-78-6
Degarelix 3D分子结构 CAS号:214766-78-6
规格 价格 会员价 库存 数量
{[ item.pr_size ]}

{[ getRatePrice(item.pr_rmb, 1,1) ]}

{[ getRatePrice(item.pr_rmb_sale, 1,1) ]}

{[ getRatePrice(item.pr_rmb, 1,1) ]}

{[ getRatePrice(item.pr_rmb,item.pr_rate,1) ]}
{[ getRatePrice(item.pr_rmb, 1,1) ]} {[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_rmb,1,item.mem_rate) ]} 现货 咨询 - +
购物车0 收藏 询单

Degarelix 纯度/质量文件 产品仅供科研

货号:A890488 标准纯度: {[allProObj[0].p_purity_real_show]}
批次查询: 批次纯度:

全球学术期刊中引用的产品

JACS Au, 2024. Ambeed. [ A148168 ]
JMC, 2024. Ambeed. [ A187643 ]
JMC, 2024. Ambeed. [ A341145 , A633512 , A607865 , A167774 ]
Biomacromolecules, 2024. Ambeed. [ A110759 ]
Biomacromolecules, 2024. Ambeed. [ A203543 ]
更多 >

Degarelix 生物活性

描述 Blockage of gonadrotropin-releasing hormone (GnRH) receptor (GnRHR) leads to a decrease in both luteinizing hormone (LH) and follicle-stimulating hormone (FSH) release from the pituitary, and subsequently testosterone production from testes is suppressed. Degarelix is a GnRHR antagonist used in patients with prostate cancer (PCa) who need androgen deprivation therapy (ADT). In vitro, cell viability of different prostate cells was decreased after 24, 48, or 72h of treatment with 10 μM degarelix. Furthermore, degarelix treatment induced a significant increase on caspase 3/7 activation compared to control in normal, hyperplasia, and cancer cells indicating that cells were undergoing apoptosis using the caspase cascade[3]. In vivo, at single subcutaneous injections of 0.3 to 10 μg/kg in rats, degarelix produced a dose-dependent suppression of the pituitary-gonadal axis as revealed by the decrease in plasma LH and testosterone levels[4].

Degarelix 参考文献

[1]Sakai M, Martinez-Arguelles DB, et al. In search of the molecular mechanisms mediating the inhibitory effect of the GnRH antagonist degarelix on human prostate cell growth. PLoS One. 2015 Mar 26;10(3):e0120670.

[2]Rick FG, Block NL, et al. An update on the use of degarelix in the treatment of advanced hormone-dependent prostate cancer. Onco Targets Ther. 2013 Apr 16;6:391-402.

[3]Sakai M, Martinez-Arguelles DB, et al. In search of the molecular mechanisms mediating the inhibitory effect of the GnRH antagonist degarelix on human prostate cell growth. PLoS One. 2015 Mar 26;10(3):e0120670

[4]Broqua P, Riviere PJ, Conn PM, Rivier JE, Aubert ML, Junien JL. Pharmacological profile of a new, potent, and long-acting gonadotropin-releasing hormone antagonist: degarelix. J Pharmacol Exp Ther. 2002 Apr;301(1):95-102

Degarelix 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

0.61mL

0.12mL

0.06mL

3.06mL

0.61mL

0.31mL

6.13mL

1.23mL

0.61mL

Degarelix 技术信息

CAS号214766-78-6
分子式C82H103ClN18O16
分子量 1632.259
别名 Degarelix游离 ;Degarelix acetate
运输蓝冰
存储条件

粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月

溶解度

DMSO: 9 mg/mL(5.51 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

H2O: 5 mg/mL(3.06 mM),配合低频超声,并水浴加热至45℃助溶

动物实验配方
Ambeed 相关网站 Ambeed.cn Ambeed.com
Ambeed
关于我们
联系我们
资讯中心
网站地图
产品手册
  • 批次文件查询
  • 客户支持
    专业术语
    缩略词释义
    质量手册
    产品咨询
    计算器
    活动政策
    订购方法
    活动声明
    联系我们
    400-920-2911 sales@ambeed.cn tech@ambeed.cn
    Ambeed 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务,不为任何个人或者非科研性质用途提供服务。