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描述 | The hepatitis C virus (HCV) is an enveloped, single-strand, positive-sense RNA virus in the Flaviviridae family. The HCV NS5B polymerase has multiple binding sites that can be targeted for inhibition of HCV replication. ABT-333 is a nonnucleoside inhibitor of the RNA-dependent RNA polymerase encoded by the HCV NS5B gene. It inhibited recombinant NS5B polymerases derived from HCV genotype 1a and 1b clinical isolates, with IC50 values between 2.2 and 10.7 nM. In the HCV subgenomic replicon system, dasabuvir inhibited genotype 1a (strain H77) and 1b (strain Con1) replicons with EC50 values of 7.7 and 1.8 nM, respectively. This level of activity was retained against a panel of chimeric subgenomic replicons that contained HCV NS5B genes from 22 genotype 1 clinical isolates from treatment-naive patients, with EC50s ranging between 0.15 and 8.57 nM[3]. |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
NCT02460133 | Hepatitis C Virus | Phase 4 | Active, not recruiting | June 2018 | - |
NCT03423641 | - | Completed | - | - | |
NCT02057003 | - | Recruiting | December 2020 | Spain ... 展开 >> Valme University Hospital Recruiting Seville, Spain, 41014 Contact: Karin Neukam, PhD 0034955015799 karin.neukam@gmail.com Contact: Juan A Pineda, MD 0034955015684 japineda@telefonica.net 收起 << | |
计算器 | ||||
存储液制备 | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
2.03mL 0.41mL 0.20mL |
10.13mL 2.03mL 1.01mL |
20.26mL 4.05mL 2.03mL |
CAS号 | 1132935-63-7 |
分子式 | C26H27N3O5S |
分子量 | 493.575 |
别名 | 达塞布韦 ;ABT-333 |
运输 | 蓝冰 |
存储条件 |
In solvent -20°C:3-6个月-80°C:12个月 Pure form Sealed in dry,Store in freezer, under -20°C |
溶解方案 |
DMSO: 45 mg/mL(91.17 mM),注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO 以下溶解方案都请先按照体外实验的方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议现用现配,当天使用; 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶
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动物实验配方 |