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描述 | D-Sorbitol (Sorbitol) is a six-carbon sugar alcohol and can used as a stabilizing excipient and/or isotonicity agent, sweetener, humectant, thickener and dietary supplement. In oral liquids, D-Sorbitol (Sorbitol) is used as a sugar substitute and as a drug stabilizer. D-Sorbitol (Sorbitol) is also used as a solubility enhancer for drugs such as indomethacin. D-Sorbitol (Sorbitol) is commonly used as a stabilizing excipient and/or isotonicity agent in both liquid and lyophilized parenteral protein formulations. D-Sorbitol (Sorbitol) is used in topical formulations as a humectant[2]. D-Sorbitol acts as a competitive inhibitor with a Ki of 5.5 mM against D-glucose, D-xylose, and D-ribose[3]. The hepatic clearance of D-sorbitol was proven to be a reliable parameter for evaluating the functional liver plasma flow[4]. In normal and under septic conditions, hepatic clearance of D-sorbitol either by bolus or a SS (steady-state) infusion is comparable[5]. |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
NCT03257436 | Left Ventricular Dysfunction | Not Applicable | Recruiting | July 2020 | - |
NCT00642148 | Pulmonary Disease, Chronic Obs... 展开 >>tructive 收起 << | Phase 2 | Completed | - | - |
NCT01726504 | Constipation | Phase 2 | Completed | - | China, Beijing ... 展开 >> Guang'anmen Hospital of China Academy of Chinese Medical Sciences Beijing, Beijing, China, 100700 收起 << |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
5.49mL 1.10mL 0.55mL |
27.45mL 5.49mL 2.74mL |
54.89mL 10.98mL 5.49mL |
CAS号 | 50-70-4 |
分子式 | C6H14O6 |
分子量 | 182.172 |
别名 | 山梨醇 ;Sorbitol;D-Glucitol;Glucitol |
运输 | 蓝冰 |
存储条件 |
粉末 Inert atmosphere,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 |
DMSO: 105 mg/mL(576.38 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO H2O: 100 mg/mL(548.93 mM),配合低频超声助溶 |
动物实验配方 |