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/ Cysteamine hydrochloride

半胱胺盐酸盐 /Cysteamine hydrochloride {[allProObj[0].p_purity_real_show]}

货号：A542078 同义名： 2-巯基乙基胺盐酸盐 / 2-Aminoethanethiol hydrochloride;2-Mercaptoethylamine hydrochloride

Cysteamine HCl is biosynthesized by the degradation of coenzyme A in mammals, mainly used in the treatment of cystinosis.

Cysteamine hydrochloride 化学结构 CAS号：156-57-0
Cysteamine hydrochloride 化学结构
CAS号：156-57-0
Cysteamine hydrochloride 3D分子结构
CAS号：156-57-0
Cysteamine hydrochloride 化学结构 CAS号：156-57-0
Cysteamine hydrochloride 3D分子结构 CAS号：156-57-0
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Cysteamine hydrochloride 纯度/质量文件 产品仅供科研

货号：A542078 标准纯度： {[allProObj[0].p_purity_real_show]}
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Cysteamine hydrochloride 生物活性

描述 Cysteamine hydrochloride (2-Aminoethanethiol hydrochloride) is an orally active agent for the treatment of nephropathic cystinosis and an antioxidant[1]. Cysteamine hydrochloride (2-Aminoethanethiol hydrochloride) effectively increases intracellular glutathione levels in cystinotic cells, helping to restore their altered redox state. It demonstrates a dose-dependent impact on the doxorubicin-induced death of cancer cells, with significant effects observed in both HeLa and B16 cells. Notably, while Cysteamine hydrochloride alone does not affect cell survival, its combination with doxorubicin significantly enhances cell death in doxorubicin-resistant breast cancer cell lines, highlighting its potential to improve chemotherapy outcomes[1]. Additionally, at a concentration of 100 μM, Cysteamine hydrochloride markedly boosts intracellular glutathione (GSH) levels and enhances the developmental progression of embryos, significantly increasing the proportion of matured oocytes that reach the blastocyst stage in culture[2].
体外研究

Cysteamine hydrochloride (2-Aminoethanethiol hydrochloride) is an orally active agent for the treatment of nephropathic cystinosis and an antioxidant[1].

Cysteamine hydrochloride (2-Aminoethanethiol hydrochloride) effectively increases intracellular glutathione levels in cystinotic cells, helping to restore their altered redox state. It demonstrates a dose-dependent impact on the doxorubicin-induced death of cancer cells, with significant effects observed in both HeLa and B16 cells. Notably, while Cysteamine hydrochloride alone does not affect cell survival, its combination with doxorubicin significantly enhances cell death in doxorubicin-resistant breast cancer cell lines, highlighting its potential to improve chemotherapy outcomes[1].

Additionally, at a concentration of 100 μM, Cysteamine hydrochloride markedly boosts intracellular glutathione (GSH) levels and enhances the developmental progression of embryos, significantly increasing the proportion of matured oocytes that reach the blastocyst stage in culture[2].

Cysteamine hydrochloride 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00074516 - Completed - United States, Maryland ... 展开 >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 收起 <<
NCT00006466 Multiple Myeloma and Plasma Ce... 展开 >>ll Neoplasm Precancerous Condition 收起 << Phase 1 Phase 2 Unknown - United States, Georgia ... 展开 >> Emory Clinic Atlanta, Georgia, United States, 30322 United States, Maryland Victory Over Cancer Rockville, Maryland, United States, 20852 United States, New York St. Vincents Comprehensive Cancer Center New York, New York, United States, 10011 收起 <<
NCT00041379 Lymphoma Phase 1 Phase 2 Unknown - United States, Maryland ... 展开 >> Victory Over Cancer Rockville, Maryland, United States, 20852 收起 <<

Cysteamine hydrochloride 参考文献

[1]Besouw, M., et al., Cysteamine: an old drug with new potential. Drug Discov Today, 2013. 18(15-16): p. 785-92.

[2]de Matos, D.G., et al., Effect of cysteamine on glutathione level and developmental capacity of bovine oocyte matured in vitro. Mol Reprod Dev, 1995. 42(4): p. 432-6.

Cysteamine hydrochloride 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

8.80mL

1.76mL

0.88mL

44.01mL

8.80mL

4.40mL

88.02mL

17.60mL

8.80mL

Cysteamine hydrochloride 技术信息

CAS号156-57-0
分子式C2H8ClNS
分子量 113.61
别名 2-巯基乙基胺盐酸盐 ;2-Aminoethanethiol hydrochloride;2-Mercaptoethylamine hydrochloride;β-Mercaptoethylamine;CI-9148;Cysteamine (hydrochloride);Mercaptamine;Cysteamine HCl
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,2-8°C
溶解度

DMSO: 105 mg/mL(924.22 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 50 mg/mL(440.1 mM)
动物实验配方

Tags: Cysteamine hydrochloride | 2-Aminoethanethiol hydrochloride;2-Mercaptoethylamine hydrochloride;β-Mercaptoethylamine;CI-9148;Cysteamine (hydrochloride);Mercaptamine;Cysteamine HCl | 2-巯基乙基胺盐酸盐 | Inflammation Model | AmBeed-信号通路专用抑制剂 | Cysteamine hydrochloride 纯度/质量文件 | Cysteamine hydrochloride 生物活性 | Cysteamine hydrochloride 临床数据 | Cysteamine hydrochloride 参考文献 | Cysteamine hydrochloride 实验方案 | Cysteamine hydrochloride 技术信息

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