Cyclosporin H is a potent and effective inhibitor of formyl peptide receptor (FPR) with Ki of 0.1 uM.
HazMat Fee +
There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
As an initial signal in the innate immunity, the formyl peptide stimulates leukocyte chemotaxis, induces acute and chronic inflammation, and stimulates the release of a number of the cytokine storm mediators from monocytes, neutrophils and endothelial cells by acting through the formyl peptide receptor (FPR). Cyclosporin H, a potent anti-inflammatory compound, acts as a specific competitive antagonist of formyl peptides on FPR on phagocytic: leukocytes. Cyclosporin H completely blocked neutrophil chemotaxis induced by the standard formyl peptide, f-MLF, as well as the bacteria-derived or host-derived formyl peptide[1]. Cyclosporin H (8 to 800 nM) concentration-dependently inhibited histamine and leukotriene C4 release from purified and unpurified basophils activated by FMLP. Furthermore, Cyclosporin H inhibited tritiated FMLP binding to human polymorphonuclear leukocytes with a concentration required to inhibit binding by 50% of approximately 0.54 nM[2]. In vivo treatment by Cyclosporin H in the mouse model of HINI Swine flu influenza infection for 5 days markedly reduced lung inflammation and endothelial cell damage[1].
搜索
HazMat Fee +
