考拉西坦 /Coluracetam
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货号：A103396
同义名：
MKC-231;BCI-540
Coluracetam a nootropic which can increase the potency of AMPA receptors.
Coluracetam 化学结构
Coluracetam 3D分子结构
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Coluracetam 纯度/质量文件 产品仅供科研
货号：A103396
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Coluracetam 质控信息
Coluracetam 生物活性
描述
Coluracetam (MKC-231) a new choline uptake enhancer. MKC-231(10(-10)-10(-6) moll) significantly increased high affinity choline uptake (HACU) when it was incubated with the hippocampal synaptosomes of ethylcholine mustard aziridinium ion (AF64A) treated rats, but not of normal rats. Oral administration of MKC-231 (1-10 mg/kg) significantly improved the learning deficits in the Morris' water maze of AF64A-treated rats[3] [4]
Coluracetam 参考文献
[1] Dutta A, McKie S, Deakin JF. Ketamine and other potential glutamate antidepressants. Psychiatry Res. 2015 Jan 30;225(1-2):1-13.
[2] Murai S, Saito H, et al. MKC-231, a choline uptake enhancer, ameliorates working memory deficits and decreased hippocampal acetylcholine induced by ethylcholine aziridinium ion in mice. J Neural Transm Gen Sect. 1994;98(1):1-13.
[3] Bessho T, Takashina K, Tabata R, Ohshima C, Chaki H, Yamabe H, Egawa M, Tobe A, Saito K. Effect of the novel high affinity choline uptake enhancer 2-(2-oxopyrrolidin-1-yl)-N-(2,3-dimethyl-5,6,7,8-tetrahydrofuro[2,3-b] quinolin-4-yl)acetoamide on deficits of water maze learning in rats. Arzneimittelforschung. 1996 Apr;46(4):369-73. PMID: 8740080.
[4] Murai S, Saito H, Abe E, Masuda Y, Odashima J, Itoh T. MKC-231, a choline uptake enhancer, ameliorates working memory deficits and decreased hippocampal acetylcholine induced by ethylcholine aziridinium ion in mice. J Neural Transm Gen Sect. 1994;98(1):1-13. doi: 10.1007/BF01277590. PMID: 7710736.
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Coluracetam 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
2.93mL
0.59mL
0.29mL
14.65mL
2.93mL
1.46mL
29.29mL
5.86mL
2.93mL
Coluracetam 技术信息
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