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/ Chlorhexidine 2HCl

氯己定二盐酸盐 /Chlorhexidine 2HCl {[allProObj[0].p_purity_real_show]}

货号：A235907 同义名： 盐酸氯己定 / Chlorhexidine (hydrochloride);NSC-185

Chlorhexidine 2HCl is a biguanide compound used as an antiseptic agent with topical antibacterial activity.

Chlorhexidine 2HCl 化学结构 CAS号：3697-42-5
Chlorhexidine 2HCl 化学结构
CAS号：3697-42-5
Chlorhexidine 2HCl 3D分子结构
CAS号：3697-42-5
Chlorhexidine 2HCl 化学结构 CAS号：3697-42-5
Chlorhexidine 2HCl 3D分子结构 CAS号：3697-42-5
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Chlorhexidine 2HCl 纯度/质量文件 产品仅供科研

货号：A235907 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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Chlorhexidine 2HCl 生物活性

描述 Chlorhexidine Dihydrochloride (CHX) has proven antimicrobial activity, excellent substantivity, low surface tension, and low cytotoxicity and genotoxicity that depend on the dose and exposed area[3]. CHX-IBU (chlorhexidine dihydrochloride - ibuprofen) loaded ISFI (in-situ forming implants) could be efficient as adjuvant to periodontal therapy for the control of infection and inflammation[4]. Moreover, CHX decreased in a concentration-dependend manner the number of attached gingival epithelial cells and PDL (periodontal ligament) fibroblasts. Rinsing with CHX may prevent or at least retard bacterial colonization on membrane exposed to the oral activity[5].

Chlorhexidine 2HCl 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02169167 Diabetes Mellitus ... 展开 >> Diabetes Complications Diabetic Neuropathies Wound Infection 收起 << Not Applicable Completed - Poland ... 展开 >> Diabetic Foot Clinic Regional Diabetic Centre, Department of Hypertension and Diabetology Gdańsk, Poland, 80-952 收起 <<
NCT00515151 Catheterization, Central Venou... 展开 >>s Catheter-Associated Infections Bacterial Infections Bacteremia 收起 << Phase 4 Completed - Germany ... 展开 >> Institute of Environmental Medicine and Hospital Epidemiology University Medical Center Freiburg Freiburg, Germany Switzerland Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel Basel, Switzerland 收起 <<
NCT03224299 Preoperative Skin Preparation Phase 2 Completed - United States, Montana ... 展开 >> BioScience Laboratories Bozeman, Montana, United States, 59718 BioScience Laboratories Butte, Montana, United States, 59701 收起 <<

Chlorhexidine 2HCl 参考文献

[1]Maki DG, Ringer M, Alvarado CJ. Prospective randomised trial of povidone-iodine, alcohol, and chlorhexidine for prevention of infection associated with central venous and arterial catheters. Lancet. 1991 Aug 10;338(8763):339-43.

[2]Jenkins S, Addy M, Wade W. The mechanism of action of chlorhexidine. A study of plaque growth on enamel inserts in vivo. J Clin Periodontol. 1988 Aug;15(7):415-24.

[3]Bernardi A, Teixeira CS. The properties of chlorhexidine and undesired effects of its use in endodontics. Quintessence Int. 2015 Jul-Aug;46(7):575-82.

[4]Batool F, Agossa K, Lizambard M, Petit C, Bugueno IM, Delcourt-Debruyne E, Benkirane-Jessel N, Tenenbaum H, Siepmann J, Siepmann F, Huck O. In-situ forming implants loaded with chlorhexidine and ibuprofen for periodontal treatment: Proof of concept study in vivo. Int J Pharm. 2019 Oct 5;569:118564.

[5]Rudolf JL, Moser C, Sculean A, Eick S. In-vitro antibiofilm activity of chlorhexidine digluconate on polylactide-based and collagen-based membranes. BMC Oral Health. 2019 Dec 26;19(1):291.

Chlorhexidine 2HCl 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.73mL

0.35mL

0.17mL

8.64mL

1.73mL

0.86mL

17.29mL

3.46mL

1.73mL

Chlorhexidine 2HCl 技术信息

CAS号3697-42-5
分子式C22H32Cl4N10
分子量 578.369
别名 盐酸氯己定 ;Chlorhexidine (hydrochloride);NSC-185;CHX;Chlorhexidine 2HCl;Chlorhexidine dihydrochloride
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,Room Temperature
溶解度

DMSO: 20 mg/mL(34.58 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

2% DMSO+30% PEG 300+2% Tween 80+water 3 mg/mL

Tags: Chlorhexidine | 3697-42-5 | Bacterial Inhibitor | Anti-infection | Bacterial | Antibiotic | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Chlorhexidine 2HCl 纯度/质量文件 | Chlorhexidine 2HCl 生物活性 | Chlorhexidine 2HCl 临床数据 | Chlorhexidine 2HCl 参考文献 | Chlorhexidine 2HCl 实验方案 | Chlorhexidine 2HCl 技术信息

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