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头孢噻吩 /Cephalothin {[allProObj[0].p_purity_real_show]}

货号：A437484 同义名： Cephalotin;Cephalothinum

Cephalothin是一种头孢类抗生素，具有抗菌活性。

Cephalothin 化学结构
CAS号：153-61-7

Cephalothin 3D分子结构
CAS号：153-61-7

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Cephalothin 纯度/质量文件产品仅供科研

货号：A437484 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Neuron, 2025. Ambeed. [ A1440350 ]; • Nature Communications, 2025, 16, 996. Ambeed. [ A111960 , A505336 ]; • JACS, 2025. Ambeed. [ A349578 , A2270125 ]; • PLoS Biol., 2025, 23(2): e3002961. Ambeed. [ A181909 ]; • Redox Rep., 2025, 30(1): 2454887. Ambeed. [ A1155014 ]; 更多 >

Cephalothin 生物活性

描述

Cephalotin (Cephalotin) is a beta-lactam antibiotic, inhibits class C β-lactamase AmpC, with an Ki of 0.32 µM^[1]. The maximum plasma cephalothin concentration after IM administration was 11.3 +/- 3.71 micrograms/ml. The terminal half-life was 47.0 minutes and was longer than the half-life after IV administration. The bioavailability of cephalothin given IM ranged from 38.3% to 93.1% and averaged 65.0 +/- 20.5%^[2]. Two derivatives of cephalothin, compound I and II, were synthesized and demonstrated strong growth inhibition of ampicillin resistant Escherichia coli (E. coli). The MIC50 of I and II were determined to be 55 microg/mL and 30 microg/mL, respectively. Cephalothin showed less than 20% growth inhibition of E. coli at all concentrations based on assay of colony forming units. Compounds I and II showed greater than 50% growth inhibition of E. coli at all concentrations greater than 50 microg/mL (more than 65% at 400 microg/mL)^[3]. Patients receiving intravenous sodium cephalothin or intravenous penicillin-G. Immunogenicity was indicated by a higher incidence of anti-cephalothin antibody in patients after having received the drug than in controls and by an increase in titre of anti-cephalothin antibody during administration of the drug. Further, patients receiving cephalothin had a high incidence of anti-penicillin antibodies and the anti-penicillin antibody titre increased during cephalothin administration^[4].

Cephalothin 参考文献

[1]Morandi S, Morandi F, Caselli E, Shoichet BK, Prati F. Structure-based optimization of cephalothin-analogue boronic acids as beta-lactamase inhibitors. Bioorg Med Chem. 2008;16(3):1195‐1205

[2]Ruoff WW Jr, Sams RA. Pharmacokinetics and bioavailability of cephalothin in horse mares. Am J Vet Res. 1985;46(10):2085‐2090

[3]Bartzatt R, Cirillo SL, Cirillo JD. Derivatives of cephalothin that inhibit ampicillin resistant Escherichia coli. Med Chem. 2007;3(1):45‐49

[4]Abraham GN, Petz LD, Fudenberg HH. Immunohaematological cross-allergenicity between penicillin and cephalothin in humans. Clin Exp Immunol. 1968;3(4):343‐357

Cephalothin 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

2.52mL

0.50mL

0.25mL

12.61mL

2.52mL

1.26mL

25.22mL

5.04mL

2.52mL

Cephalothin 技术信息

CAS号	153-61-7
分子式	C₁₆H₁₆N₂O₆S₂
分子量	396.438

别名	Cephalotin;Cephalothinum;Spaly Brand of Cephalothin Sodium;Sodium Cephalothin;Seffin;Salt, Cephalothin Monosodium;Normon Brand of Cephalothin Sodium;Monosodium Salt, Cephalothin;Cefalotina;Cefalothin;Cefalotin;Cephalotin acid
运输	蓝冰

存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Keep in dark place,Sealed in dry,Room Temperature

溶解方案

细胞实验：

DMSO: 105 mg/mL(264.86 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验：请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用；以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

方案一

方案二

动物实验配方

头孢噻吩 /Cephalothin {[allProObj[0].p_purity_real_show]}

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Cephalothin 质控信息

Cephalothin 生物活性

Cephalothin 参考文献

Cephalothin 实验方案

Cephalothin 技术信息

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头孢噻吩 /Cephalothin {[allProObj[0].p_purity_real_show]}

Cephalothin 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

Cephalothin 质控信息

Cephalothin 生物活性

Cephalothin 参考文献

Cephalothin 实验方案

Cephalothin 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

Cephalothin 纯度/质量文件产品仅供科研