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头孢菌素C锌盐 /Cephalosporin C zinc salt {[allProObj[0].p_purity_real_show]}

货号:A164198 同义名: Cephalosporin C (zinc)

Cephalosporin C zinc salt is a potent inhibitor of SAMHD1 with an IC50 of 1.1 μM.

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Cephalosporin C zinc salt 化学结构 CAS号:59143-60-1
Cephalosporin C zinc salt 化学结构
CAS号:59143-60-1
Cephalosporin C zinc salt 3D分子结构
CAS号:59143-60-1
Cephalosporin C zinc salt 化学结构 CAS号:59143-60-1
Cephalosporin C zinc salt 3D分子结构 CAS号:59143-60-1
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Cephalosporin C zinc salt 纯度/质量文件 产品仅供科研

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Cephalosporin C zinc salt 生物活性

描述 Cephalosporin C zinc salt is a potent inhibitor of SAMHD1 (Sterile alpha motif and histidine-aspartate domain-containing protein 1) with an IC50 of 1.1 ± 0.1 μM, 200-fold more potent than Na+ salt form of Cephalosporin C (ICC50CC-Na = 213 ± 30 μM). Cephalosporin C zinc salt is an antibiotic used to study the effect of transpeptidase expression, binding, and inhibition on bacterial cell wall mucopeptide synthesis. Cephalosporin C zinc salt, as is expected of a Cephalosporin, will disrupt the synthesis of the peptidoglycan layer of bacterial cell walls[2]. A loss in activity of the zinc-activated enzyme which occurred on prolonged hydrolysis of cephalosporin C was not restored by further addition of zinc[3]. The minimum inhibitory concentration of cephalosporin C(A) (pyridine) upon penicillinase-producing staphylococci increased 4 to 8-fold with a 500-fold increase in inoculum size; with cephalosporin C there was a 2-fold increase. Cephalosporin C(A) (pyridine) was about 8 times more active than cephalosporin C in protecting mice from an experimental streptococcal infection, nine doses of 6.25 mg/kg affording complete protection[4].

Cephalosporin C zinc salt 参考文献

[2]Seamon KJ, Stivers JT. A High-Throughput Enzyme-Coupled Assay for SAMHD1 dNTPase. J Biomol Screen. 2015 Jul;20(6):801-9

[3]Sabath LD, Finland M. Thiol-group binding of zinc to a beta-lactamase of Bacillus cereus: differential effects on enzyme activity with penicillin and cephalosporins as substrates. J Bacteriol. 1968 May;95(5):1513-9

[4]JAGO M, HEATLEY NG. Some biological properties of cephalosporin C and a derivative. Br J Pharmacol Chemother. 1961 Apr;16(2):170-9

Cephalosporin C zinc salt 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.09mL

0.42mL

0.21mL

10.44mL

2.09mL

1.04mL

20.89mL

4.18mL

2.09mL

Cephalosporin C zinc salt 技术信息

CAS号59143-60-1
分子式C16H19N3O8SZn
分子量 478.81
别名 Cephalosporin C (zinc)
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Inert atmosphere,2-8°C

溶解度

DMSO: 4 mg/mL(8.35 mM),配合低频超声,并调节pH至3,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

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