货号:A164198 同义名: Cephalosporin C (zinc)
Cephalosporin C zinc salt is a potent inhibitor of SAMHD1 with an IC50 of 1.1 μM.
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Type | HazMat fee for 500 gram (Estimated) |
Excepted Quantity | USD 0.00 |
Limited Quantity | USD 15-60 |
Inaccessible (Haz class 6.1), Domestic | USD 80+ |
Inaccessible (Haz class 6.1), International | USD 150+ |
Accessible (Haz class 3, 4, 5 or 8), Domestic | USD 100+ |
Accessible (Haz class 3, 4, 5 or 8), International | USD 200+ |
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描述 | Cephalosporin C zinc salt is a potent inhibitor of SAMHD1 (Sterile alpha motif and histidine-aspartate domain-containing protein 1) with an IC50 of 1.1 ± 0.1 μM, 200-fold more potent than Na+ salt form of Cephalosporin C (ICC50CC-Na = 213 ± 30 μM). Cephalosporin C zinc salt is an antibiotic used to study the effect of transpeptidase expression, binding, and inhibition on bacterial cell wall mucopeptide synthesis. Cephalosporin C zinc salt, as is expected of a Cephalosporin, will disrupt the synthesis of the peptidoglycan layer of bacterial cell walls[2]. A loss in activity of the zinc-activated enzyme which occurred on prolonged hydrolysis of cephalosporin C was not restored by further addition of zinc[3]. The minimum inhibitory concentration of cephalosporin C(A) (pyridine) upon penicillinase-producing staphylococci increased 4 to 8-fold with a 500-fold increase in inoculum size; with cephalosporin C there was a 2-fold increase. Cephalosporin C(A) (pyridine) was about 8 times more active than cephalosporin C in protecting mice from an experimental streptococcal infection, nine doses of 6.25 mg/kg affording complete protection[4]. |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
2.09mL 0.42mL 0.21mL |
10.44mL 2.09mL 1.04mL |
20.89mL 4.18mL 2.09mL |
CAS号 | 59143-60-1 |
分子式 | C16H19N3O8SZn |
分子量 | 478.81 |
别名 | Cephalosporin C (zinc) |
运输 | 蓝冰 |
存储条件 |
液体 -20°C:3-6个月-80°C:12个月 粉末 Keep in dark place,Inert atmosphere,2-8°C |
溶解度 |
DMSO: 4 mg/mL(8.35 mM),配合低频超声,并调节pH至3,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO |
动物实验配方 |