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头孢西丁钠 /Cefoxitin sodium {[allProObj[0].p_purity_real_show]}

货号:A125671 同义名: 头孢西丁 钠盐 / MK-306;Cenomycin

Cefoxitin Sodium is a semi-synthetic, broad-spectrum second-generation cephamycin antibiotic.

Cefoxitin sodium 化学结构 CAS号:33564-30-6
Cefoxitin sodium 化学结构
CAS号:33564-30-6
Cefoxitin sodium 3D分子结构
CAS号:33564-30-6
Cefoxitin sodium 化学结构 CAS号:33564-30-6
Cefoxitin sodium 3D分子结构 CAS号:33564-30-6
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Cefoxitin sodium 纯度/质量文件 产品仅供科研

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Cefoxitin sodium 生物活性

描述 Cefoxitin (Sodium) is a beta-lactam antibiotic derived from cephamycin C, a naturally occurring substance produced by Streptomyces lactamdurans. Its resistance to destruction by beta-lactamases results in a broad spectrum of antibacterial activity which includes anaerobic as well as Gram-positive and Gram-negative aerobic bacteria, including many resistant to cephalothin and other cephalosporins[3]. Shenqi Fuzheng injection combined with cefoxitin sodium after cesarean section can effectively reduce the postoperative maternal body temperature and promote the recovery of maternal gastrointestinal function, which is conducive to the repair of uterus, further correct anemia after cesarean section and prevent postpartum infection[4]. Cefoxitin sodium was shown to maintain 90% of its initial concentration in aqueous solution for 40 hours at room temperature (25 °C) and about 30 days at 5 °C[5].

Cefoxitin sodium 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03053401 Post-operative Pain ... 展开 >> Quadriceps Muscle Strength 收起 << Not Applicable Recruiting June 30, 2019 United States, Ohio ... 展开 >> Akron Children's Hospital Recruiting Akron, Ohio, United States, 44308 Contact: Rami E Karroum, MD    330-543-8823    rkarroum@chmca.org    Contact: Ibrahim Farid, MD    330-543-8823    ifarid@chmca.org    Sub-Investigator: Ibrahim Farid, MD          Sub-Investigator: Paul Fleissner, MD          Sub-Investigator: Elizabeth Kendrick, MSN,RN          Sub-Investigator: Jonathan Klein, DO          Sub-Investigator: George Youssef, MD 收起 <<
NCT00726622 Colorectal Cancer Phase 3 Active, not recruiting - -
NCT00719303 Fallopian Tube Clear Cell Aden... 展开 >>ocarcinoma Fallopian Tube Endometrioid Adenocarcinoma Fallopian Tube Mucinous Adenocarcinoma Fallopian Tube Serous Adenocarcinoma Fallopian Tube Transitional Cell Carcinoma Malignant Ovarian Brenner Tumor Ovarian Clear Cell Adenocarcinoma Ovarian Endometrioid Adenocarcinoma Ovarian Mucinous Adenocarcinoma Ovarian Seromucinous Carcinoma Ovarian Serous Adenocarcinoma Ovarian Transitional Cell Carcinoma Primary Peritoneal Serous Adenocarcinoma Stage IIA Fallopian Tube Cancer AJCC v6 and v7 Stage IIA Ovarian Cancer AJCC V6 and v7 Stage IIB Fallopian Tube Cancer AJCC v6 and v7 Stage IIB Ovarian Cancer AJCC v6 and v7 Stage IIC Fallopian Tube Cancer AJCC v6 and v7 Stage IIC Ovarian Cancer AJCC v6 and v7 Stage IIIA Fallopian Tube Cancer AJCC v7 Stage IIIA Ovarian Cancer AJCC v6 and v7 Stage IIIA Primary Peritoneal Cancer AJCC v7 Stage IIIB Fallopian Tube Cancer AJCC v7 Stage IIIB Ovarian Cancer AJCC v6 and v7 Stage IIIB Primary Peritoneal Cancer AJCC v7 Stage IIIC Fallopian Tube Cancer AJCC v7 Stage IIIC Ovarian Cancer AJCC v6 and v7 Stage IIIC Primary Peritoneal Cancer AJCC v7 Stage IV Fallopian Tube Cancer AJCC v6 and v7 Stage IV Ovarian Cancer AJCC v6 and v7 Stage IV Primary Peritoneal Cancer AJCC v7 Undifferentiated Fallopian Tube Carcinoma Undifferentiated Ovarian Carcinoma 收起 << Phase 3 Recruiting - -

Cefoxitin sodium 参考文献

[1]van Hoogdalem EJ, Hardens MA, et al. Absorption enhancement of rectally infused cefoxitin sodium by medium-chain fatty acids in conscious rats: concentration-effect relationship. Pharm Res. 1988 Jul;5(7):453-6.

[2]Nishihata T, Higuchi T. Promoting effect of concanavalin A on transport of sodium cefoxitin and phenol red from rat rectal compartment. Life Sci. 1984 Jan 30;34(5):419-26.

[3]Brogden RN, Heel RC, Speight TM, Avery GS. Cefoxitin: a review of its antibacterial activity, pharmacological properties and therapeutic use. Drugs. 1979 Jan;17(1):1-37.

[4]Chen J, Cheng Y, Ma X, Cao Y. Observation on Shenqi Fuzheng injection combined with cefoxitin sodium after cesarean section. Pak J Pharm Sci. 2017 Jul;30(4(Suppl.)):1475-1478.

[5]O'Brien MJ, Portnoff JB, Cohen EM. Cefoxitin sodium compatibility with intravenous infusions and additives. Am J Hosp Pharm. 1979 Jan;36(1):33-8.

Cefoxitin sodium 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.23mL

0.45mL

0.22mL

11.13mL

2.23mL

1.11mL

22.25mL

4.45mL

2.23mL

Cefoxitin sodium 技术信息

CAS号33564-30-6
分子式C16H16N3NaO7S2
分子量 449.434
别名 头孢西丁 钠盐 ;MK-306;Cenomycin;Merck Sharp and Dohme Brand of Cefoxitin Sodium;Merck Frosst Brand of Cefoxitin Sodium;Merck Brand of Cefoxitin Sodium;Sodium, Cefoxitin;MSD Brand of Cefoxitin Sodium;Cefoxitin sodium salt;Merxin;Farmoxin;Betacef;Cefoxitin (sodium salt)
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Inert atmosphere,2-8°C

溶解度

DMSO: 105 mg/mL(233.63 mM),注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

H2O: 100 mg/mL(222.5 mM)

动物实验配方
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