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头孢噻肟钠盐 /Cefotaxime sodium {[allProObj[0].p_purity_real_show]}

货号:A468233 同义名: 头孢噻肟钠 / Cefotaxim sodium;HR-756 sodium

Cefotaxime Sodium is a semisynthetic third-generation cephalosporin antibiotic used to treat joint infections, pelvic inflammatory disease, meningitis, pneumonia, urinary tract infections, sepsis, gonorrhea, and cellulitis.

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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Cefotaxime sodium 化学结构 CAS号:64485-93-4
Cefotaxime sodium 化学结构
CAS号:64485-93-4
Cefotaxime sodium 3D分子结构
CAS号:64485-93-4
Cefotaxime sodium 化学结构 CAS号:64485-93-4
Cefotaxime sodium 3D分子结构 CAS号:64485-93-4
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Cefotaxime sodium 纯度/质量文件 产品仅供科研

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Cefotaxime sodium 生物活性

描述 The cefotaxime sodium spectrum of activity is very broad and includes many common species and a variety of less frequently isolated pathogens. Cefotaxime was consistently active against Actinobacillus actinomycetemcomitans, Capnocytophaga spp, Eikenella corrodens, Erysipelothrix rhusiopathiae, Pasteurella multocida, Plesiomonas shigelloides, and Fusobacterium nucleatum[3]. The stability of cefotaxime sodium was dependent on the surface area of the excipient in contact with the drug[4]. Ceftriaxone may be more versatile having the additional apparent benefits of reducing other postoperative infections, being less dependent on metronidazole as an adjunct and providing a more effective prophylactic cover against Staphylococcus aureus[5]. Moreover, Ceftriaxone and cefotaxime are both effective in the treatment of bacterial meningitis[6].

Cefotaxime sodium 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03067805 Sexual Infidelity ... 展开 >> Emotional Infidelity Jealousy 收起 << Not Applicable Recruiting November 2019 China, Sichuan ... 展开 >> School of Life Science and Technology, University of Electronic Science and Technology Recruiting Chengdu, Sichuan, China, 611731 Contact: Qin Li, Master       helenlee@uestc.edu.cn 收起 <<
NCT03053401 Post-operative Pain ... 展开 >> Quadriceps Muscle Strength 收起 << Not Applicable Recruiting June 30, 2019 United States, Ohio ... 展开 >> Akron Children's Hospital Recruiting Akron, Ohio, United States, 44308 Contact: Rami E Karroum, MD    330-543-8823    rkarroum@chmca.org    Contact: Ibrahim Farid, MD    330-543-8823    ifarid@chmca.org    Sub-Investigator: Ibrahim Farid, MD          Sub-Investigator: Paul Fleissner, MD          Sub-Investigator: Elizabeth Kendrick, MSN,RN          Sub-Investigator: Jonathan Klein, DO          Sub-Investigator: George Youssef, MD 收起 <<
NCT00726622 Colorectal Cancer Phase 3 Active, not recruiting - -

Cefotaxime sodium 参考文献

[1]Woodfield JC, Van Rij AM, et al. A comparison of the prophylactic efficacy of ceftriaxone and cefotaxime in abdominal surgery. Am J Surg. 2003 Jan;185(1):45-9.

[2]Scholz H, Hofmann T, et al. Prospective comparison of ceftriaxone and cefotaxime for the short-term treatment of bacterial meningitis in children. Chemotherapy. 1998 Mar-Apr;44(2):142-7.

[3]Cormican MG, Jones RN. Antimicrobial activity of cefotaxime tested against infrequently isolated pathogenic species (unusual pathogens). Diagn Microbiol Infect Dis. 1995;22(1-2):43–48

[4]Al-Nimry SS, Alkhamis KA, Alzarieni KZ. The Effect of Specific Surface Area of Chitin-Metal Silicate Coprocessed Excipient on the Chemical Decomposition of Cefotaxime Sodium. J Pharm Sci. 2017;106(2):570–578

[5]Woodfield JC, Van Rij AM, Pettigrew RA, van der Linden AJ, Solomon C, Bolt D. A comparison of the prophylactic efficacy of ceftriaxone and cefotaxime in abdominal surgery. Am J Surg. 2003;185(1):45–49

[6]Scholz H, Hofmann T, Noack R, Edwards DJ, Stoeckel K. Prospective comparison of ceftriaxone and cefotaxime for the short-term treatment of bacterial meningitis in children. Chemotherapy. 1998;44(2):142–147

Cefotaxime sodium 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.09mL

0.42mL

0.21mL

10.47mL

2.09mL

1.05mL

20.94mL

4.19mL

2.09mL

Cefotaxime sodium 技术信息

CAS号64485-93-4
分子式C16H16N5NaO7S2
分子量 477.447
别名 头孢噻肟钠 ;Cefotaxim sodium;HR-756 sodium;CTX;Cefotaxime (sodium salt);HR-756
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Inert atmosphere,2-8°C

溶解度

DMSO: 45 mg/mL(94.25 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

H2O: 50 mg/mL(104.72 mM),配合低频超声助溶

动物实验配方
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