Cefoperazone is a third-generation β-lactam cephalosporin antibiotic which can bind to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, causing the inhibition of the third and last stage of bacterial cell wall synthesis.
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HazMat fee for 500 gram (Estimated)
Excepted Quantity
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USD 80+
Inaccessible (Haz class 6.1), International
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Cefoperazone is a third‐generation cephalosporin and is one of a small number of cephalosporins that are effective in treating Pseudomonas bacterial infections (MIC50 25 μg/mL). The hydrolysis product of cefoperazone was noncovalently bound in the active site of PBP3. This may be important in the design of new noncovalent PBP3 inhibitors[3]. After intramuscular injection of 2 g of cefoperazone, the mean peak serum level was 111 microgram/ml at 1.5 hours. At 12 hours after dosing, mean serum levels were still 2 to 4 microgram/ml. Cefoperazone was 90% bound to serum proteins[4]. Both the inhibitory potency of the cephalosporins for Mrp2-mediated (multidrug resistance-associated protein) transport and the uptake of cephalosporins by Mrp2-expressing vesicles were molecular weight-dependent[5].
United States, Kentucky
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University of Louisville
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Louisville, Kentucky, United States, 40202
Contact: Julio A Ramirez, MD 502-852-1148 jarami01@louisville.edu
Contact: David Seligson, MD 502-852-0923 d0seli01@louisville.edu
Sub-Investigator: Forest Arnold, DO
Sub-Investigator: Timothy Wiemkwn, PhD
Sub-Investigator: Robert Kelley, PhD
Sub-Investigator: James Summersgill, PhD
Sub-Investigator: Ruth Carrico, PhD
Sub-Investigator: Julie Harting, PharmD
Sub-Investigator: Paula Peyrani, MD
Principal Investigator: David Seligson, MD
Sub-Investigator: Craig Roberts, MD
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Neutropenia, Febrile
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Phase 3
Recruiting
December 2018
India
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Contact: Sameer Bakhshi, MD 011-29575237 sambakh@hotmail.com 收起 <<
China, Jiangsu
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Nanjing, Jiangsu, China
Contact: hong wh wang, doctor 025-83714511 ext 6360
Sub-Investigator: mao hm huang, doctor 收起 <<
United States, Kentucky
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University of Louisville
Recruiting
Louisville, Kentucky, United States, 40202
Contact: Julio A Ramirez, MD 502-852-1148 jarami01@louisville.edu
Contact: David Seligson, MD 502-852-0923 d0seli01@louisville.edu
Sub-Investigator: Forest Arnold, DO
Sub-Investigator: Timothy Wiemkwn, PhD
Sub-Investigator: Robert Kelley, PhD
Sub-Investigator: James Summersgill, PhD
Sub-Investigator: Ruth Carrico, PhD
Sub-Investigator: Julie Harting, PharmD
Sub-Investigator: Paula Peyrani, MD
Principal Investigator: David Seligson, MD
Sub-Investigator: Craig Roberts, MD
Principal Investigator: Julio Ramirez, MD 收起 <<
Neutropenia, Febrile
... 展开 >> Pediatric Cancer 收起 <<
Phase 3
Recruiting
December 2018
India
... 展开 >> Department of Medical Oncology, AIIMS
Recruiting
New Delhi, India, 110029
Contact: Sameer Bakhshi, MD 011-29575237 sambakh@hotmail.com 收起 <<
China, Jiangsu
... 展开 >> the First Affiliated Hospital With Medical University
Recruiting
Nanjing, Jiangsu, China
Contact: hong wh wang, doctor 025-83714511 ext 6360
Sub-Investigator: mao hm huang, doctor 收起 <<
India
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Pfizer Investigational Site
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Pfizer Investigational Site
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Pfizer Investigational Site
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Pfizer Investigational Site
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Pfizer Investigational Site
Chandigarh, India, 160 012
Pfizer Investigational Site
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Hyderabad, India
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Pfizer Investigational Site
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