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/ Cefdinir

头孢地尼 /Cefdinir {[allProObj[0].p_purity_real_show]}

货号：A123828 同义名： CI-983;FK-482

Cefdinir是一种半合成的广谱抗生素，属于第三代头孢菌素类，主要用于治疗耳部、鼻窦、喉部和皮肤的常见细菌感染。

HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Cefdinir 化学结构 CAS号：91832-40-5
Cefdinir 化学结构
CAS号：91832-40-5
Cefdinir 3D分子结构
CAS号：91832-40-5
Cefdinir 化学结构 CAS号：91832-40-5
Cefdinir 3D分子结构 CAS号：91832-40-5
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Cefdinir 纯度/质量文件 产品仅供科研

货号：A123828 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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Cefdinir 生物活性

描述 Cefdinir is a third-generation cephalosporin with a broad spectrum of antibacterial activity encompassing pathogens that are commonly causative in infections of the respiratory tract or skin and skin structure. Cefdinir is stable to hydrolysis by commonly occurring plasmid-mediated beta-lactamases and retains good activity against beta-lactamase-producing strains of H. influenzae and M. catarrhalis[3]. Subjects assigned to cefdinir exhibited notable, improvements in tic symptoms, compared with the placebo group[4]. Moreover, cefdinir inhibited Gly-Sar uptake, but with low affinity, resulting in 50% inhibitory concentrations (or Ki values) on the order of 10 to 20 mM for both transporters (PEPT1 and PEPT2)[5].

Cefdinir 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01511107 Acute Otitis Media Phase 2 Terminated(The primary objecti... 展开 >>ve of the study was met.) 收起 << - United States, Kentucky ... 展开 >> Kentucky Pediatric/Adult Research Bardstown, Kentucky, United States, 40004 United States, Pennsylvania Children's Hospital of Pittsburgh of UPMC Pittsburgh, Pennsylvania, United States, 15224 收起 <<
NCT01734759 Healthy Phase 1 Completed - United States, Minnesota ... 展开 >> Mayo Clinic in Rochester Rochester, Minnesota, United States, 55905 收起 <<
NCT01511107 - Terminated(The primary objecti... 展开 >>ve of the study was met.) 收起 << - -

Cefdinir 参考文献

[1]Lepsy CS, Guttendorf RJ, et al. Effects of organic anion, organic cation, and dipeptide transport inhibitors on cefdinir in the isolated perfused rat kidney. Antimicrob Agents Chemother. 2003 Feb;47(2):689-96.

[2]Labro MT, el Benna J, et al. Cefdinir (CI-983), a new oral amino-2-thiazolyl cephalosporin, inhibits human neutrophil myeloperoxidase in the extracellular medium but not the phagolysosome. J Immunol. 1994 Mar 1;152(5):2447-55.

[3]Perry CM, Scott LJ. Cefdinir: a review of its use in the management of mild-to-moderate bacterial infections. Drugs. 2004;64(13):1433-64.

[4]Murphy TK, Parker-Athill EC, Lewin AB, Storch EA, Mutch PJ. Cefdinir for recent-onset pediatric neuropsychiatric disorders: a pilot randomized trial. J Child Adolesc Psychopharmacol. 2015 Feb;25(1):57-64.

[5]Lepsy CS, Guttendorf RJ, Kugler AR, Smith DE. Effects of organic anion, organic cation, and dipeptide transport inhibitors on cefdinir in the isolated perfused rat kidney. Antimicrob Agents Chemother. 2003 Feb;47(2):689-96.

Cefdinir 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.53mL

0.51mL

0.25mL

12.65mL

2.53mL

1.26mL

25.29mL

5.06mL

2.53mL

Cefdinir 技术信息

CAS号91832-40-5
分子式C14H13N5O5S2
分子量 395.413
别名 CI-983;FK-482;BMY 28488;PD 134393
运输蓝冰
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Keep in dark place,Sealed in dry,2-8°C
溶解方案

DMSO: 35 mg/mL(88.51 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
方案一
方案二
动物实验配方

Tags: Cefdinir | 91832-40-5 | FK-482 | CI-983 | FK482 | FK 482 | CI983 | CI 983 | CI-983 | Bacterial Inhibitor | Anti-infection | Bacterial | Antibiotic | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Cefdinir 纯度/质量文件 | Cefdinir 生物活性 | Cefdinir 临床数据 | Cefdinir 参考文献 | Cefdinir 实验方案 | Cefdinir 技术信息

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