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二醋酸卡泊芬净 /Caspofungin diacetate {[allProObj[0].p_purity_real_show]}

货号:A587048 同义名: 二醋酸卡泊芬净 / MK-0991 diacetate;L-743872 diacetate

Caspofungin acetate is an lipopeptide antifungal β-1,3-glucan synthase inhibitor.

Caspofungin diacetate 化学结构 CAS号:179463-17-3
Caspofungin diacetate 化学结构
CAS号:179463-17-3
Caspofungin diacetate 3D分子结构
CAS号:179463-17-3
Caspofungin diacetate 化学结构 CAS号:179463-17-3
Caspofungin diacetate 3D分子结构 CAS号:179463-17-3
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Caspofungin diacetate 纯度/质量文件 产品仅供科研

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Caspofungin diacetate 生物活性

描述 Caspofungin acetate (Diacetate) is an antifungal antibiotic that inhibits synthesis of 1,3-beta-D-glucan, an essential component of the fungal cell wall. Extended incubation of A. fumigatus with a single dose of caspofungin affected the same proportion of apical and subapical branching cells for up to 72 h. The dye-staining patterns illustrate that the cells at the active centers for new cell wall synthesis within A. fumigatus hyphae are killed when they are exposed to caspofungin[3]. Caspofungin (CPFG) showed an excellent effect against FN (febrile neutropenia) (75%, 18/24), without any serious hepatic or renal toxicity. The high efficacy, safety, and tolerability of CPFG as an empirical antifungal therapy for Japanese patients with FN[4]. Caspofungin may be considered as a component of combination antifungal regimens. Caspofungin represents a significant advance in the care of patients with serious fungal infections[5].

Caspofungin diacetate 参考文献

[1]McGee WT, Tereso GJ. Successful treatment of Candida krusei infection with caspofungin acetate: a new antifungal agent. Crit Care Med. 2003 May;31(5):1577-8.

[2]Bartizal K, Gill CJ, et al. In vitro preclinical evaluation studies with the echinocandin antifungal MK-0991 (L-743,872). Antimicrob Agents Chemother. 1997 Nov;41(11):2326-32.

[3]Bowman JC, Hicks PS, Kurtz MB, Rosen H, Schmatz DM, Liberator PA, Douglas CM. The antifungal echinocandin caspofungin acetate kills growing cells of Aspergillus fumigatus in vitro. Antimicrob Agents Chemother. 2002 Sep;46(9):3001-12

[4]Shibata Y, Miyahara Y, Sadaka Y, Yasue M, Fujimura M, Soda M, Yamamoto M, Kato H, Suzuki A, Tsukamoto K, Hara T, Tsurumi H, Kitaichi K. Evaluation of the effectiveness of caspofungin against febrile neutropenia and the factors related to the alteration in its plasma concentration. J Infect Chemother. 2019 Oct;25(10):801-805

[5]Morrison VA. Caspofungin: an overview. Expert Rev Anti Infect Ther. 2005 Oct;3(5):697-705

Caspofungin diacetate 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

0.82mL

0.16mL

0.08mL

4.12mL

0.82mL

0.41mL

8.24mL

1.65mL

0.82mL

Caspofungin diacetate 技术信息

CAS号179463-17-3
分子式C56H96N10O19
分子量 1213.417
别名 二醋酸卡泊芬净 ;MK-0991 diacetate;L-743872 diacetate;MK 0991;Caspofungin (acetate);L-743872;Caspofungin Acetate
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,Store in freezer, under -20°C

溶解度

DMSO: 105 mg/mL(86.53 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

H2O: 100 mg/mL(82.41 mM)

动物实验配方
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