CP 376395 (10-20 mg/kg, i.p., Male B6 mice) reduces H2O and food consumption, enhances sucrose intake, decreases ethanol intake, but does not affect ethanol preference^[2].

CP 376395 completely inhibits oCRF-induced adenylate cyclase activity in the rat cerebral cortex and at human CRF1 receptors, with an apparent Ki value of 12 nM, demonstrating its antagonist activity. It exhibits high selectivity for the human CRF1 receptor subtype, with an affinity for the CRF2 receptor exceeding 10,000 nM. Additionally, it displays affinities greater than 1 µM for 40 other neurotransmitter receptors and ion channels^[1].