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/ Beclometasone Dipropionate

丙酸倍氯米松 /Beclometasone Dipropionate {[allProObj[0].p_purity_real_show]}

货号：A739014 同义名： 二丙酸倍氯米松 / Beclomethasone dipropionate

Beclometasone dipropionate, a prodrug of beclometasone, is a glucocorticoid agonist which is used to treat rhinitis and sinusitis.

Beclometasone Dipropionate 化学结构 CAS号：5534-09-8
Beclometasone Dipropionate 化学结构
CAS号：5534-09-8
Beclometasone Dipropionate 3D分子结构
CAS号：5534-09-8
Beclometasone Dipropionate 化学结构 CAS号：5534-09-8
Beclometasone Dipropionate 3D分子结构 CAS号：5534-09-8
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Beclometasone Dipropionate 纯度/质量文件 产品仅供科研

货号：A739014 标准纯度： {[allProObj[0].p_purity_real_show]}
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Beclometasone Dipropionate 生物活性

描述 Betamethasone dipropionate, the prodrug of Betamethasone, is an orally active and potent glucocorticoid with anti-inflammatory and immunosuppressive activity. Betamethasone appears to be an effective inhibitor of LPS-induced inflammation and MMP release. When mice were pretreated with betamethasone (5 mg/kg, po), MMP2 and MMP9 activities, TNF-alpha in BAL fluids, and the enhanced neutrophil number of LPS-exposed mice were reduced, whereas the level of IL-10 was increased[3]. Oral BDP (Beclometasone Dipropionate) gave an overall treatment result in patients with active ulcerative colitis without signs of systemic side-effects[4]. Sustained clinical and histological remission was induced with the topical steroid preparation, beclometasone dipropionate (Clipper), with no adverse effects[5]. Beclometasone dipropionate (BDP) is a topically active corticosteroid with low absorption into the systemic circulation, which minimises many of the deleterious side effects associated with systemic corticosteroids[6].

Beclometasone Dipropionate 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00854360 Seasonal Allergic Rhinitis ... 展开 >> Hayfever 收起 << Phase 2 Completed - -
NCT00854360 - Completed - -
NCT01345916 Asthma Phase 3 Completed - Poland ... 展开 >> GSPZOZ Uniwersytecki Szpital Kliniczny Łódź, Poland, 90-153 收起 <<

Beclometasone Dipropionate 参考文献

[1]Ratner PH, Melchior A, et al. Pharmacokinetic profile of beclomethasone dipropionate hydrofluoroalkane after intranasal administration versus oral inhalation in healthy subjects: results of a single-dose, randomized, open-label, 3-period crossover study. Clin Ther. 2012 Jun;34(6):1422-31.

[2]Busse WW, Brazinsky S, et al. Efficacy response of inhaled beclomethasone dipropionate in asthma is proportional to dose and is improved by formulation with a new propellant. J Allergy Clin Immunol. 1999 Dec;104(6):1215-22.

[3]Corbel M, Lagente V, Théret N, Germain N, Clément B, Boichot E. Comparative effects of betamethasone, cyclosporin and nedocromil sodium in acute pulmonary inflammation and metalloproteinase activities in bronchoalveolar lavage fluid from mice exposed to lipopolysaccharide. Pulm Pharmacol Ther. 1999;12(3):165-71

[4]Campieri M, Adamo S, Valpiani D, D'Arienzo A, D'Albasio G, Pitzalis M, Cesari P, Casetti T, Castiglione GN, Rizzello F, Manguso F, Varoli G, Gionchetti P. Oral beclometasone dipropionate in the treatment of extensive and left-sided active ulcerative colitis: a multicentre randomised study. Aliment Pharmacol Ther. 2003 Jun 15;17(12):1471-80

[5]Ibraheim H, Green M, Papa S, Powell N. Topical beclometasone dipropionate in the management of immune checkpoint inhibitor-induced microscopic colitis. BMJ Case Rep. 2019 Apr 3;12(4):e226481

[6]Díez-Campelo M, Sánchez-Guijo FM, Pérez-Simón JA. Beclometasone dipropionate: a topically active corticosteroid for the treatment of gastrointestinal graft-versus-host disease. Expert Opin Investig Drugs. 2008 Sep;17(9):1389-401

Beclometasone Dipropionate 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.92mL

0.38mL

0.19mL

9.60mL

1.92mL

0.96mL

19.19mL

3.84mL

1.92mL

Beclometasone Dipropionate 技术信息

CAS号5534-09-8
分子式C28H37ClO7
分子量 521.042
别名 二丙酸倍氯米松 ;Beclomethasone dipropionate
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Sealed in dry,2-8°C
溶解度

DMSO: 105 mg/mL(201.52 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

Tags: Beclometasone | 5534-09-8 | Beclomethasone dipropionate | Glucocorticoid Receptor | Glucocorticoid Receptor Agonist | Immunology/Inflammation | Vitamin D Related/Nuclear Receptor | NF-κB | Metabolic Enzyme/Protease | Glucocorticoid Receptor | Reactive Oxygen Species | NO Synthase | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Beclometasone Dipropionate 纯度/质量文件 | Beclometasone Dipropionate 生物活性 | Beclometasone Dipropionate 临床数据 | Beclometasone Dipropionate 参考文献 | Beclometasone Dipropionate 实验方案 | Beclometasone Dipropionate 技术信息

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