Baloxavir是一种新型的帽依赖性核酸内切酶(CEN)抑制剂,用于治疗甲型和乙型流感病毒感染。它通过抑制病毒 RNA 转录和复制展现出强大的抗病毒活性,有助于改善流感的治疗策略。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
50μL*10mM(DMSO) | ¥179 | 咨询 | |
100μL*10mM(DMSO) | ¥289 | 咨询 | |
250μL*10mM(DMSO) | ¥579 | 咨询 | |
500μL*10mM(DMSO) | ¥959 | 咨询 | |
10mM*1mL(DMSO) | ¥1415 | 咨询 | |
1mg | ¥210 | 咨询 | |
5mg | ¥252 | 咨询 | |
10mg | ¥303 | 咨询 | |
25mg | ¥364 | 咨询 | |
50mg | ¥437 | 咨询 | |
100mg | ¥525 | 咨询 | |
250mg | ¥630 | 咨询 | |
1g | ¥2519 | 咨询 |
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描述 | Baloxavir, derived from the prodrug Baloxavir marboxil, is a potent, selective cap-dependent endonuclease (CEN) inhibitor of the PA subunit of influenza A and B viral polymerase, a first-in-class inhibitor of viral RNA transcription and replication, and possesses potent antiviral activity. Baloxavir inhibits both cap-dependent endonuclease (CEN) and cap-dependent endonuclease (CEN). Baloxavir inhibits cap-dependent endonuclease (CEN) and CEN/RdRp activity with IC50 values of 2.5 nM and 1.6 nM, respectively, while the inhibitory efficacy against RdRp activity is low (IC50 >40 nM)[1][2].The median EC50 values of Baloxavir against A/H1N1pdm, A/H3N2 and B viruses were 17.96 nM, 4.48 nM and 18.67 nM, respectively[1].Baloxavir inhibits viral RNA transcription by inhibiting cap-dependent endonuclease (CEN) activity, and inhibits viral replication in infected cells without cytotoxicity in cytopathic effect assays. Baloxavir has a broad spectrum of efficacy against various subtypes of influenza A viruses (H1N2, H5N1, H5N2, H5N6, H7N9 and H9N2). In addition, sequential passaging of the viruses in the presence of Baloxavir resulted in the isolation of PA/I38T variants with reduced susceptibility to BXA. Baloxavir showed high potency to inhibit CEN activity in the tested influenza A and B virus ribonucleoprotein complexes (vRNPs), with mean IC50 values of 1.4-3.1 nM and 4.5-8.9 nM, respectively, indicating broad-spectrum activity. Baloxavir was highly potent against influenza A and B viruses, with mean EC90 values of 0.46-0.98 nM and 2.2-3.4 nM, respectively[2]. |
计算器 | ||||
存储液制备 | ![]() | 1mg | 5mg | 10mg |
1 mM 5 mM 10 mM | 2.07mL 0.41mL 0.21mL | 10.34mL 2.07mL 1.03mL | 20.68mL 4.14mL 2.07mL |
CAS号 | 1985605-59-1 |
分子式 | C24H19F2N3O4S |
分子量 | 483.49 |
别名 | |
运输 | 蓝冰 |
存储条件 | In solvent -20°C:3-6个月-80°C:12个月 Pure form Sealed in dry,2-8°C |
溶解方案 | DMSO: 40 mg/mL(82.73 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO 以下溶解方案都请先按照体外实验的方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议现用现配,当天使用; 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶
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