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首页 / 抑制剂/激动剂 / 抗感染 / 流感病毒 / Baloxavir marboxil

Baloxavir marboxil {[allProObj[0].p_purity_real_show]}

货号：A267027

Baloxavir marboxil is an inhibitor of cap-dependent endonuclease of influenza A and B viruses.

Baloxavir marboxil 化学结构 CAS号：1985606-14-1
Baloxavir marboxil 化学结构
CAS号：1985606-14-1
Baloxavir marboxil 3D分子结构
CAS号：1985606-14-1
Baloxavir marboxil 化学结构 CAS号：1985606-14-1
Baloxavir marboxil 3D分子结构 CAS号：1985606-14-1
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Baloxavir marboxil 纯度/质量文件 产品仅供科研

货号：A267027 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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Baloxavir marboxil 生物活性

描述 Seasonal and pandemic influenza are the two faces of respiratory infections caused by influenza viruses in humans. Influenza virus infection may result in pneumonia and acute respiratory failure, frequently complicated by bacterial coinfection[1]. Baloxavir marboxil is a small molecule inhibitor of the cap-dependent endonuclease of influenza A and B viruses. Baloxavir marboxil is a prodrug that is metabolised to an active form (known as S‐033447) which is highly effective at inhibiting a number of different influenza A and B viruses in vitro[2]. In a mouse model of infection, a single dose of Baloxavir marboxil was found to reduce viral load by 2 logs and reduced mortality compared to mice being treated with oseltamivir. In a phase II study of S‐033188, patients with uncomplicated influenza were randomised to three different doses (10 mg, 20 mg and 40 mg) and compared to placebo. All three doses resulted in significant reductions in time to alleviation of symptoms and reduced virus titres at 24 and 48 hours post‐treatment compared to placebo[2].

Baloxavir marboxil 参考文献

[1]Peteranderl C, Herold S, Schmoldt C. Human Influenza Virus Infections. Semin Respir Crit Care Med. 2016 Aug;37(4):487-500. doi: 10.1055/s-0036-1584801. Epub 2016 Aug 3. PMID: 27486731; PMCID: PMC7174870.

[2]Koszalka P, Tilmanis D, Hurt AC. Influenza antivirals currently in late-phase clinical trial. Influenza Other Respir Viruses. 2017 May;11(3):240-246. doi: 10.1111/irv.12446. Epub 2017 Feb 28. PMID: 28146320; PMCID: PMC5410715.

Baloxavir marboxil 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.75mL

0.35mL

0.17mL

8.75mL

1.75mL

0.87mL

17.50mL

3.50mL

1.75mL

Baloxavir marboxil 技术信息

CAS号1985606-14-1
分子式C27H23F2N3O7S
分子量 571.549
别名
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Sealed in dry,Store in freezer, under -20°C
溶解度

DMSO: 35 mg/mL(61.24 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

Tags: Baloxavir marboxil | Influenza Virus | AmBeed-信号通路专用抑制剂 | Baloxavir marboxil 纯度/质量文件 | Baloxavir marboxil 生物活性 | Baloxavir marboxil 参考文献 | Baloxavir marboxil 实验方案 | Baloxavir marboxil 技术信息

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