BNTA是一种有效的细胞外基质 (ECM) 调节剂,能够通过激活 SOD3 促进软骨细胞中软骨结构分子的合成,显示出对骨关节炎具有潜在的治疗作用,适用于关节软骨修复和骨关节炎研究。
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描述 | BNTA, a potent modulator of the extracellular matrix (ECM), enhances the synthesis of cartilage structural molecules in chondrocytes by activating superoxide dismutase 3 (SOD3). BNTA exhibits promising potential for alleviating osteoarthritis by regulating cartilage formation[1]. |
体内研究 | BNTA (0.015-1.5 mg/kg; intra-articular injection; twice a week for 4 and 8 weeks) effectively mitigated the progression of osteoarthritis induced by anterior cruciate ligament transection (ACLT) in rats[1]. |
体外研究 | BNTA (0.01-10 μM; 1-7 days) does not reduce the viability of human osteoarthritis chondrocytes and rat primary chondrocytes[1]. NTA (0.1 μM; 2 days) significantly enhances SOX9 protein expression[1]. NTA (0.1 μM; 2 days) markedly elevates the levels of COL2A1 and SOX9 proteins in IL1β-induced rat OA chondrocytes[1]. NTA (10 μM; 5 days) enhances proteoglycan staining in ATDC5 cells[1]. NTA (0.01-10 μM; 6 hours) increases the expression levels of ECM-related genes COL2A1, ACAN, proteoglycan 4 (PRG4), and SRY-box 9 (SOX9) in human OA chondrocytes[1]. NTA (0.01-10 μM; 6 hours) enhances the mRNA levels of Col2a1, Acan, Prg4, and Sox9, with peak effects observed around 0.1 μM in IL1β-induced rat OA chondrocytes[1]. NTA (0.01-1 μM; 2 or 3 weeks) promotes anabolism and suppresses inflammatory response in osteoarthritis cartilage explants[1]. |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
2.19mL 0.44mL 0.22mL |
10.95mL 2.19mL 1.09mL |
21.89mL 4.38mL 2.19mL |
CAS号 | 685119-25-9 |
分子式 | C17H11BrClNO3S2 |
分子量 | 456.761 |
别名 | |
运输 | 蓝冰 |
存储条件 |
粉末 Keep in dark place,Inert atmosphere,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 |
DMSO: 105 mg/mL(229.88 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO |
动物实验配方 |