货号:A119196 同义名: 两性霉素B / LNS-AmB;NSC 527017
Amphotericin B 是一种广谱抗真菌药物,通过与真菌细胞膜中的麦角固醇结合,干扰膜的通透性。Amphotericin B 主要用于治疗系统性真菌感染,如念珠菌病和曲霉病。
规格 | 价格 | 会员价 | 库存 | 数量 | |||
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描述 | Amphotericin B (AmB) is the most effective drug for treating many life-threatening fungal infections. TLR2 (Toll-like receptors) and CD14 are required for amphotericin B-dependent inflammatory stimulation of innate immune cells and that TLR4 may also provide stimulation of these cells[1]. AmB only kills unicellular Leishmania promastigotes (LPs) when aqueous pores permeable to small cations and anions are formed. At low concentrations (≤0.1 microM), AmB was found to be nonlethal against LPs but, above this concentration, leishmanias were rapidly killed[3]. Amphotericin B treatment of hamsters infected with scrapie strain 263K prolongs the incubation period of the disease [4]. |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
NCT00163111 | Candidiasis | Phase 3 | Completed | - | - |
NCT00370825 | Visceral Leishmaniasis | Phase 2 | Completed | - | India ... 展开 >> Kala-azar Medical Research Center Muzaffarpur, Bihar, India, 842001 收起 << |
NCT00002742 | Chronic Myeloproliferative Dis... 展开 >>orders Infection Leukemia Lymphoma Multiple Myeloma and Plasma Cell Neoplasm Myelodysplastic Syndromes 收起 << | Phase 3 | Completed | - | - |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
1.08mL 0.22mL 0.11mL |
5.41mL 1.08mL 0.54mL |
10.82mL 2.16mL 1.08mL |
CAS号 | 1397-89-3 |
分子式 | C47H73NO17 |
分子量 | 924.079 |
别名 | 两性霉素B ;LNS-AmB;NSC 527017;Fungizone |
运输 | 蓝冰 |
存储条件 |
液体 -20°C:3-6个月-80°C:12个月 粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
溶解度 |
DMSO: 50 mg/mL(54.11 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO |
动物实验配方 |
IP 2% DMSO+2% Tween80+30% PEG300+water 1 mg/mL clear PO 0.5% CMC-Na 36 mg/mL suspension |