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Acrinol Monohydrate {[allProObj[0].p_purity_real_show]}

货号:A550852 同义名: 乳酸依沙吖啶一水物;利凡诺 / Ethacridine lactate monohydrate; Acrinol monohydrat

Acrinol Monohydrate是一种抗菌剂和流产剂,主要用于抗革兰氏阳性细菌,且作为聚 (ADP-核糖) 糖基水解酶(PARG)抑制剂。

Acrinol Monohydrate 化学结构 CAS号:6402-23-9
Acrinol Monohydrate 化学结构
CAS号:6402-23-9
Acrinol Monohydrate 3D分子结构
CAS号:6402-23-9
Acrinol Monohydrate 化学结构 CAS号:6402-23-9
Acrinol Monohydrate 3D分子结构 CAS号:6402-23-9
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Acrinol Monohydrate 纯度/质量文件 产品仅供科研

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Acrinol Monohydrate 生物活性

描述 Ethacridine (Lactate Monohydrate) is used as a topical antiseptic as well as for second-trimester abortion. And ethacridine is an inhibitor of poly (ADP-ribose) glycohydrolase (PARG) and an activator of the transcriptional coactivator with PDZ-binding motif (TAZ). Ethacridine elicits apoptotic cell death in thyroid cancer cells and promotes differentiation in a subset of thyroid follicular cells[3]. Extra-amniotic ethacridine lactate instillation alone and intracervical PGE2 (prostaglandin E2) gel application are effective and safe methods for second trimester abortion[4]. Mifepristone combined with ethacridine lactate is safe and effective for patients with low placentation or/and prior cesarean in the second-trimester pregnancy termination[5].

Acrinol Monohydrate 参考文献

[1]Junka A, et al. Int Wound J, 2013.

[2]Junka A, Bartoszewicz M, et al. Efficacy of antiseptics containing povidone-iodine, octenidine dihydrochloride and ethacridine lactate against biofilm formed by Pseudomonas aeruginosa and Staphylococcus aureus measured with the novel biofilm-oriented antiseptics test. Int Wound J. 2014 Dec;11(6):730-4.

[3]Huang TS, Lee JJ, Li YS, Cheng SP. Ethacridine Induces Apoptosis and Differentiation in Thyroid Cancer Cells In Vitro. Anticancer Res. 2019;39(8):4095‐4100

[4]Inan I, Kelekçi S, Yazar D. Comparison of ethacridine lactate and prostaglandin E2 in second trimester medical abortion. Acta Obstet Gynecol Scand. 1997;76(7):680‐683

[5]Chen C, Lin F, Wang X, Jiang Y, Wu S. Mifepristone combined with ethacridine lactate for the second-trimester pregnancy termination in women with placenta previa and/or prior cesarean deliveries. Arch Gynecol Obstet. 2017;295(1):119‐124

Acrinol Monohydrate 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.77mL

0.55mL

0.28mL

13.84mL

2.77mL

1.38mL

27.67mL

5.53mL

2.77mL

Acrinol Monohydrate 技术信息

CAS号6402-23-9
分子式C18H23N3O5
分子量 361.39
SMILES Code NC1=CC2=NC3=CC=C(OCC)C=C3C(N)=C2C=C1.CC(O)C(O)=O.[H]O[H]
MDL No. MFCD00149646
别名 乳酸依沙吖啶一水物;利凡诺;乳酸依沙吖啶 一水合物 ;Ethacridine lactate monohydrate; Acrinol monohydrat; Ethodin; Rivanol monohydrate; Ethacridine(lactate monohydrate)
运输蓝冰
InChI Key NYEPHMYJRNWPLA-UHFFFAOYSA-N
Pubchem ID 165457
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Sealed in dry,2-8°C

溶解方案

DMSO: 105 mg/mL(290.54 mM),注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

H2O: 2 mg/mL(5.53 mM),配合低频超声助溶

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