Acoramidis HCl
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货号：A1544116
同义名：
AG10 hydrochloride;Acoramidis hydrochloride
Ac oramidis HCl蛋白 (TTR ) 稳定剂，能够有效稳定野生型和 V122I 突变型 TTR ，具有潜力用于研究转甲状腺素 淀粉样变性疾病。
Acoramidis HCl 化学结构
Acoramidis HCl 3D分子结构
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Acoramidis HCl 纯度/质量文件 产品仅供科研
货号：A1544116
标准纯度：
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Acoramidis HCl 质控信息
Acoramidis HCl 生物活性
描述
Acoramidis HCl is an orally active, selective kinetic stabiliser of wild-type and V122I mutant TTR (transthyretin).Acoramidis HCl is used in the study of transthyretin amyloidosis[1] [2] [1] [3] [1]
Acoramidis HCl 参考文献
[1] Sravan C Penchala, et al. AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin. Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9992-7.
[2] Jonathan C Fox, et al. First-in-Human Study of AG10, a Novel, Oral, Specific, Selective, and Potent Transthyretin Stabilizer for the Treatment of Transthyretin Amyloidosis: A Phase 1 Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Study in Healthy Adult Volunteers. Clin Pharmacol Drug Dev. 2020 Jan;9(1):115-129.
[3] Stephen P Soltoff, et al. Evidence that tyrphostins AG10 and AG18 are mitochondrial uncouplers that alter phosphorylation-dependent cell signaling. J Biol Chem. 2004 Mar 19;279(12):10910-8.
Acoramidis HCl 实验方案
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1mg
5mg
10mg
1 mM
5 mM
10 mM
3.04mL
0.61mL
0.30mL
15.21mL
3.04mL
1.52mL
30.42mL
6.08mL
3.04mL
Acoramidis HCl 技术信息
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