5-Fluorocytosine is an antimycotic prodrug which can be converted to 5-fluorouracil, working by inhibiting DNA and RNA synthesis and interfering with ribosomal protein synthesis. It shows both antifungal and antitumor activity.
Flucytosine (5-FC, 5-Fluorocytosine) is a synthetic antimycotic compound. In combination with amphotericin B, 5-FC can be used to treat severe systemic mycoses, such as cryptococcosis, candidosis, chromoblastomycosis and aspergillosis. Moreover, 5-FC has been combined with newer azole antifungal agents; it also plays an important role in a new approach to the treatment of cancer. The severe side effects of 5-FC include hepatotoxicity and bone-marrow depression[3]. 5-FC half-life in the serum of 10 rabbits increased from 3.35 +/- 0.27 to 24.63 +/- 0.70 hr after experimentally induced acute renal failure. Concentrations of 5-FC in the cerebrospinal fluid of five patients ranged from 17 to 62 mug/ml and were 74.4 +/- 5.6% of simultaneously determined serum concentrations[4]. The 5FC-FCZ (fluconazole, FCZ) combination was antagonistic against Candida species, but for some Candida isolates synergism was found. For C. neoformans the interaction for both combinations was highly dependent on the tested isolate and the method used[5].
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