货号：A376712同义名：
Bromopyruvic acid;Hexokinase II Inhibitor II, 3-BP
3-Bromopyruvic acid is an inhibitor of hexokinase II with effective antitumor acitvity.
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HazMat fee for 500 gram (Estimated)
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Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
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Accessible (Haz class 3, 4, 5 or 8), International
3-Bromopyruvate (3-BrPA) is an analogue of pyruvate and a potent hexokinase (HK)-II inhibitor with high tumor selectivity. 3-BrPA can induce growth inhibition in a dose-dependent pattern by cell apoptosis. 3-BrPA combined with rapamycin played a synergistic suppression role in NB cells, affected the cell apoptosis, cell cycle and the metabolic pathway[3]. Low concentration of 3-BrPA significantly affected both glutaminolysis and TCA cycle functions, through inhibition of isocitrate dehydrogenase, α-ketoglutarate dehydrogenase and succinate dehydrogenase. Additionally, 3-BrPA treatment significantly decreased the reduced status of thiol groups in HepG2 cells without proportional increase of oxidizing groups, suggesting that these chemical groups are the target of alkylation reactions induced by 3-BrPA[4]. 3-BrPA synergistically sensitized breast cancer cells to TRAIL‑induced apoptosis via the upregulation of death receptor 5 (DR5). And the protein levels of glucose‑related protein 78 (GRP78) and CCAAT‑enhancer‑binding protein homologous protein (CHOP) increased following treatment with 3-BrPA. 3-BrPA sensitized breast cancer cells to TRAIL via the AMPK (adenosine monophosphate-activated protein kinase)-mediated upregulation of DR5[5].
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