Podocarpusflavone A is a DNA topoisomerase I inhibitor isolated and purified from the barks of Podocarpus macrophyllus, and is the strongest noncytotoxic non-nucleotide molecule exhibiting a specific inhibitory activity against the RNA polymerase domain of DV-NS5 and thus is promising for chemotherapy development against dengue fever.

Secoisolariciresinol, a natural product isolated and purified from the Heartwood of Podocarpus spicata, exerts a suppressive effect on the gain of body weight of mice fed a high-fat diet by inducing gene expression of adiponectin, resulting in the altered expression of various genes related to the synthesis and β-oxidation of fatty acids.

Prunin, a natural product isolated and purified from the heartwood of Podocarpus macrophyllus..

Totarol has anti-bacteria effect by restraining bacterial growth by perturbing the cell division and proliferation, including several pathogenic Gram-positive bacteria, mycobacterium tuberculosis.

2,3-Dihydroheveaflavone is a natural product isolated and purified from the hertwoods of Podocarpus macrophyllus.

Nagilactone C, a natural product isolated and purified from the herbs of Podocarpus neriifolius, possesses potent antiproliferative activity against human fibrosarcoma and murine colon carcinoma tumor cell lines exhibiting ED50 values of 2.3 and 1.2 mg/mL, respectively.

2,3-Dihydroamentoflavone 7,4'-dimethyl ether is a natural product isolated and purified from the heartwoods of Podocarpus macrophyllus, exhibiting cytotoxicities (ED50 values < 4 mg/mL) against P-388 and/or HT-29 cell lines in vitro.

2,3-dihydropodocarpusflavone A is a natural product isolated and purified from the barks of Podocarpus macrophyllus.

2,3-dihydrosciadopitysin is a natural product isolated and purified from the hertwoods of Podocarpus macrophyllus.

4beta-Carboxy-19-nortotarol, a natural product isolated and purified from the heartwoods of Podocarpus macrophyllus, can inhibit microsomal lipid peroxidation induced by Fe(III)-ADP/NADPH and mitochondrial lipid peroxidation induced by Fe(III)-ADP/ NADH. It inhibits linoleic acid autoxidation but not generation of superoxide anion.