AMZ30 is a selective, covalent inhibitors of protein phosphatase methylesterase-1 (PME-1; IC50=600 nM), and selectively inactivates PME-1 and reduces the demethylated form of PP2A in living cells.

ABL127 is a potent and selective PME-1 inhibitor. It decreased the initial level of PP2Ac methylation and inhibited PP2Ac demethylation.