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CCT251236 is a HSF1 pathway inhibitor with IC50 value of 19nM for inhibition of HSF1-mediated HSP72 induction, and a tight-binding ligand of pirin with Kd value of 44nM. It displays efficacy in a human ovarian carcinoma xenograft model.
CCT-367766 (CCT367766) is a heterobifunctional PROTAC that binds and degrades the putative transcription factor regulator Pirin in cells.
Tags: Pirin | NF-κB | Pirin 相关产品
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