LM11A-31 2HCl是一种非肽 p75NTR（神经营养蛋白受体 p75）调节剂，作为口服有效的 proNGF 拮抗剂，具有良好的血脑屏障通透性，能阻断 p75 介导的细胞死亡。

PD 90780 is a non-peptide inhibitor of nerve growth factor (NGF) binding to p75NTR receptor. It inhibits NGF-p75 NTR interaction with IC50s values of 23.1 µM and 1.8 µM in PC12 cells and PC12 nnr5 cells, respectively.

Ro 08-2750 is a non-peptide and reversible nerve growth factor (NGF) inhibitor with an IC50 of ~ 1 µM which inhibits NGF binding to p75NTR selectively over TRKA. Ro 08-2750 is a selective MSI RNA-binding activity inhibitor, with an IC50 of 2.7 μM.