MLK-IN-1 是一种强效的脑渗透特异性 MLK-3 抑制剂。

Resibufogenin, a natural product isolated and purified from the glandular body of Bufo bufo gargarizans Cantor, displays great potential as a chemotherapeutic agent in oncology.

URMC-099 is an orally bioavailable, brain penetrant inhibitor of Mixed Lineage Kinase 3 (MLK3) with IC50 of 14 nM. It inhibits LPS-induced TNFα release in microglial cells, HIV-1 Tat-induced release of cytokines in human monocytes, and up-regulation of phospho-JNK in Tat-injected brains of mice.

GW806742X是一种ATP类似物，是一种有效的MLKL抑制剂，与MLKL假激酶结构域结合，Kd值为9.3μM。GW806742X具有抗VEGFR2活性(IC50=2 nM)。GW806742X可延缓MLKL膜位移，抑制坏死。

E-5324 is potent inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT) with IC50s of 44 to 190 nM.

M443 is an irreversible and specific inhibitor of MRK, with an IC50<125 nM.

CEP 1347 is an inhibitor of c-jun N-terminal kinase (JNK) signaling.