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ML-7 HCl is a multiple-target inhibitor of MLCK with Ki value of 300 nM, PKA with 21μM, and PKC of 42 μM.
Calmodulin antagonist. Inhibits myosin light chain kinase
ML 9 a is myosin light chain kinase (MLCK) inhibitor. ML-9 enhances the anticancer activity of docetaxel, suggesting its potential application as an adjuvant to existing anticancer chemotherapy. The complex effect of ML-9 on autophagy and indentified ML-9 as an attractive tool for targeting autophagy in cancer therapy through dual inhibition of both the Akt pathway and the autophagy.
Fasudil HCl (HA-1077; AT877)是一种非特异性RhoA/ROCK抑制剂,同时抑制蛋白激酶,对ROCK1的Ki为0.33 μM,对ROCK2、PKA、PKC和PKG的IC50值分别为0.158 μM、4.58 μM、12.30 μM和1.650 μM。Fasudil盐酸盐还是一种强效的Ca2+通道拮抗剂和血管扩张剂。
MLCK Inhibitor Peptide 18 is a selective competitive inhibitor of myosin light chain kinase with IC50 of 50 nM.
Tags: MLCK | 细胞骨架 | Cytoskeleton | MLCK 相关产品
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