MELK-8a hydrochloride是一种新型的母体胚胎亮氨酸拉链激酶（MELK）抑制剂，其IC50值为2 nM。

OTSSP167是一种高效的ATP竞争性MELK抑制剂，IC50值为0.41 nM。

OTSSP167 HCl is a highly potent MELK inhibitor (IC50 = 0.41 nM) and inhibited the phosphorylation of PSMA1 (proteasome subunit alpha type 1) and DBNL (drebrin-like).

JNJ-47117096 HCl is potent and selective MELK inhibitor, with an IC50 of 23 nM, also effectively inhibits Flt3, with an IC50 of 18 nM.