Genkwanin, a natural product isolated and purified from the herbs of Lobelia chinensis, exerts its anti-inflammatory effect mainly through the regulation of the miR-101/MKP-1/MAPK pathway, and is transported by both passive diffusion and multidrug resistance protein (MDR)-mediated efflux mechanisms.

Hydroxygenkwanin, a natural product isolated and purified from the herbs of Lobelia chinensis, has cytotoxicity, may be an effective natural product to treat glioma, and the combination with apigenin may be a promising method for glioma chemotherapy.