8-Epideoxyloganic acid, a natural product isolated and purified from the herb of Lamiophlomis rotata, with anti-inflammatory activity, weak antinociceptive activity and bioactivities of analgesia, homeostasis, has the potential to serve as anti-inflammatory agents during oxidative stress, the inhibition of ROS production, possibly through modulation of NOX activity and/or the radical scavenging effect, and beta2 integrin expression in leucocytes.

Shanzhiside, a natural product isolated and purified from the herb of Lamiophlomis rotata (Benth.) Kudo., shows significant inhibition of IL-2 secretion by phorbol myristate acetate and anti-CD28 monoclonal antibody co-stimulated activation of human peripheral blood T cells.