PF 06465469 is a potent inhibitor of interleukin-2 inducible T cell kinase (ITK) and also exhibits inhibitory activity against Bruton's tyrosine kinase (BTK) with IC50s of 2 nM for both of them.

Vecabrutinib is a potent BTK inhibitor, with IC50s of 4.6 nM and 1.1 nM for WT BTK and C481S BTK, respectively, and also inhibits ITK activity (IC50, 24 nM).

GSK 2250665A is an Itk inhibitor with pKi of 9.2.

BMS-509744 is a potent and selective Itk kinase inhibitor with an IC50 value of 19 nM.

CTA 056 is an Interleukin-2-inducible T-cell kinase (ITK) inhibitor with IC50 of 0.1 μM.

GNE-4997 is a potent and selective ITK/TSK inhibitor.