GPR88-IN-1是一种 GPR88 抑制剂，主要用于中枢神经系统疾病的研究，特别是在精神疾病和神经退行性疾病中，如精神分裂症和帕金森病。

(1R,2R)-2-PCCA hydrochloride is a diastereomer of 2-PCCA, and acts as a potent GPR88 agonist, with an EC50 of 3 nM.

RTI-13951-33 is a potent, selective, and brain-penetrant GPR88 agonist, with an EC50 of 25 nM in GPR88 cAMP functional assay. RTI-13951-33 reduces alcohol reinforcement and intake behaviors in rats[1].

(1S,2S)-2-PCCA HCl is a less active diastereomer of 2-PCCA. 2-PCCA is a GPR88 agonist, and inhibits GPR88-mediated cAMP production, with an EC50 of 116 nM in HEK293 cells.

AR-13324 M1 metabolite is a hydrolysis metabolite of AR-13324 mesylate.