PF-04991532 is a potent, hepatoselective glucokinase activator with EC50s of 80 and 100 nM in human and rat, respectively.

AM-2394 is a structurally distinct glucokinase activator (GKA). AM-2394 activates glucokinase (GK) with an EC50 of 60 nM.

AZD1656是一种选择性 G6PC 抑制剂，用于糖尿病的治疗研究，能够降低血糖水平。

Palmitelaidic Acid (9-trans-Hexadecenoic acid) 是反式异构体的棕榈油酸。棕榈油酸是血清和组织中最丰富的脂肪酸之一。

Dorzagliatin is a glucokinase activator on glucose metabolism.

AMG-3969 is a glucokinase-GKRP disruptor with IC50 value of 343nM and potently reverses the inhibitory effect of GKRP on GK activity.